Sanofi

Societe Anonyme Styled: Sanofi

Jean-Pierre Chambon

Kathleen Biziere

Camille-Georges Wermuth

Andre Hallot

Camille G Wermuth

Jean-Jacques Bourguignon

Jean-Charles Molimard

The invention relates to 1,2,4-triazolo [4,3-b]pyridazines substituted in the 7-position of formula: ##STR1## in which R represents hydrogen, a lower alkyl group, a phenyl group, a chlorophenyl group or a benzyl group and R.sub.1 represents a phenyl, halogenophenyl, trifluoromethylphenyl, lower alkyl-phenyl or lower alkoxy-phenyl group or a phenyl-lower alkyl group, or one of its pharmaceutically acceptable salts. Said compounds antagonize the effects of benzodiazepines and therefore are useful as antidotes in the abuse of benzodiazepines and compounds acting on benzodiazepine receptors.

Triazolo [3,4-b]pyridazines, process for their preparation and

The invention relates to the pyridazine derivatives of the formula: ##STR1## in which R.sub.1 is H, a substituted or unsubstituted phenyl group, a naphthyl group, a cyclohexyl group, a thien-2-yl group, a thien-3-yl group or an indol-3-yl group, R.sub.2 is H or an alkyl or phenyl group, R.sub.3 is H, an alkyl, or phenyl group in formula Ib and a cyano group in formula Ia, and Alk is (CH.sub.2).sub.n where n is 2, 3 or 4, or --CH.sub.2 --C.ident.C--, and X.sup.- is halide, a process for the preparation of the said products and their application as medicaments.

Pyridazine derivatives active on the central nervous system, and

The present invention relates to derivatives of pyridazine of formula: ##STR1## in which R.sub.1 is alkyl or a phenyl group and R.sub.2 is H or R.sub.1 and R.sub.2 form, with the carbon atoms to which they are attached, a benzene cycle, R.sub.3 is H or phenyl and R.sub.4 is ##STR2## in which R.sub.5 is H or CH.sub.3 and R.sub.6 is H, OH, OR or OCOR; it also relates to a process for preparing the products of formula (I) and to the drugs containing at least one of said products.

New derivatives of pyridazine active on the central nervous system

The present invention relates to the compounds of formula ##STR1## in which X.sub.1 represents N or ##STR2## X.sub.2 represents N or ##STR3## provided that X.sub.1 and X.sub.2 are different from each other; R.sub.1 and R.sub.2 being --(CH.sub.2).sub.n OH wherein n is 1 to 4 or ##STR4## represents a saturated heterocycle with 5 or 6 groupings containing one nitrogen atom as heteroatom, substituted in 3 or 4 position for example by (CH.sub.2).sub.m OR.sub.6 where R.sub.6 is H or an acyl radical or an amido radical; to a process for preparing said compounds; and to the drugs containing said compounds active in particular on the central nervous system.

Pyridazine and pyrimidine compounds active on the central nervous system

The invention relates to compounds with a nitrogen-containing heterocyclic nucleus, of the general formula: ##STR1## in which: Ar represents a group ##STR2## or a naphthyl group optionally substituted by a halogen, A represents a heterocyclic nucleus chosen from the group consisting of the pyridine, pyrimidine and triazine nuclei, and

Compounds with a nitrogen-containing heterocyclic nucleus, and drugs in

The invention relates to pyrrolidinones of the general formula: ##STR1## in which: R.sub.1 represents hydrogen or alkyl

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Montarnaud, France

Jean-Pierre Chambon