La Calhene, Inc.

Jean-Pierre Brossard

Philippe Fontcuberta

Charles Glachet

Jean-Michel Riviere

A method to mount handling equipment on an interface of a confinement chamber that is to contain a sterile environment. In the method a unit including the handling equipment is prepared and sterilized, and the chamber and a hidden part of the interface are sterilized after coupling impervious tooling to a chamber flange and partially opening the chamber door. The unit is then coupled to the interface. Finally, the double door formed by the equipment door and the chamber door connected to one another is opened, using a handle provided for this purpose on the equipment door.

Method of mounting a piece of handling equipment to a containment chamber containing a sterile medium

In order to transfer aseptic products between two enclosures ( ), use is made of a sterile container ( ) having a filling interface ( ) and an emptying interface ( ). Each interface ( ) comprises a seal ( ) behind which is placed a flexible hose ( ) equipped with a closure system ( &prime;). The filling and emptying of the container ( ) take place by connecting the corresponding interface ( ) and enclosure ( ), sterilizing the volume trapped between the seal ( ) and the door ( ) of the enclosure ( ), opening said door and also the seal and putting into place the corresponding flexible hose ( ). After filling the container ( ), the closure system ( ) of the filling interface ( ) is closed again.

Process for the transfer of aseptic products between two enclosures and transportation container for performing this process

Sterile products contained in a container (,) are transferred into a sterile isolator (,) by connecting the container onto a lock (,) fitted on the outside of the isolator (,) and equipped with a pulsed light sterilization device (,). The connection between the lock (,) and the isolator (,) is made by a sealed double door transfer device. The throwaway container is equipped with a plug type closer (,), cutout from the inside of the isolator (,) after sterilizing the volume (,) inside the lock (,) and opening the double door (,).

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Chatou, France

Jean-Pierre Brossard