Sanofi

Elf Sanofi

Jean-Pierre Bras

Danielle Gully

Daniel Frehel

Pierre Despeyroux

Robert Boigegrain

Jean-Pierre Maffrand

Gerard Valette

Alain Badorc

Paul De Cointet

Eric Bignon

Daniel Fr&eacute;hel

G&eacute;rard Valette

Heterocyclic substituted acylaminothiazoles, their preparation and pharmaceutical compositions containing them

The present invention relates to compounds of formula: ##STR1## which are agonists of cholecystokinin receptors and pharmaceutical compositions containing them.

Glycinamide derivatives, processes for their preparation and medicines

The invention relates to thiadiazole derivatives corresponding to the general formula ##STR1## in which Ar represents a nitrogen-containing aromatic heterocycle, in particular indolyl which is substituted or unsubstituted on the nitrogen atom with CO--(C.sub.1 -C.sub.4)alkyl; with (CH.sub.2).sub.n COR in which n represents 1 or 2 and R represents OR.sub.1 or NR.sub.1 R.sub.2 with R.sub.1 and R.sub.2, which may be identical or different, representing H or (C.sub.1 -C.sub.4)alkyl; with (C.sub.1 -C.sub.4) hydroxyalkyl; with (C.sub.2 -C.sub.6) alkoxyalkyl; tetrahydropyranyl; or with a --(CH.sub.2).sub.3 -- chain, the last carbon of which is attached to the phenyl ring of the indole to form a 6-membered ring;

5-acylamino-1,2,4-thiadiazoles, their preparation and pharmaceutical

Compounds of formula ##STR1## in which R.sub.1 represents H, an alkyl or a substituted alkyl, R.sub.2 represents H or alkyl and R.sub.3 represents an optionally substituted cycloalkyl or an optionally substituted aromatic group, which can be a phenyl or a heterocyclic group comprising one or more hetero-atoms chosen from O, S and N, or R.sub.2 and R.sub.3 considered together represent the group ##STR2## which is optionally substituted on the phenyl ring, and Z represents a heterocycle comprising one or more heteroatoms chosen from O, S and N, fused with an aromatic ring which can comprise a hetero-atom and can be substituted, the said heterocycle being optionally substituted on N, when it comprises such an atom, by an alkyl or a substituted alkyl group, and the salts of these compounds with acids or bases.

Heterocyclic substituted acylaminothiazoles, their preparation and

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Toulouse, France

Jean-Pierre Bras