Centre National De La Recherche Scientifique

Institut National De La Sante Et De La Recherche Medicale

Bristol-myers Squibb Compnay

Université Louis Pasteur

Universite Louis Pasteur Strasbourg

Aderegem

Jean-Pierre Bellocq

Pierre H Chambon

Paul Basset

Marie-Christine Nee Martinet Rio

Peptides derived from the pS2 protein and polyclonal and monoclonal antibodies directed against pS2 and against pS2 fragments. Method of obtaining the secreted from of the pS2 protein and fragments thereof. Method of detecting and diagnosing different pathological conditions and especially hormone-dependent breast cancers and pathological conditions of the stomach.

Peptides derived from the pS2 protein

The present invention relates to a gene encoding stromylsin-3, which is a new member of the metalloproteinase family. Expression of the stromelysin-3 gene has been found to be specifically associated with invasive breast, head, neck and skin cancer. The invention also relates to antibodies which specifically bind to human stromylsin-3 and the use of these stromelysin-3 antibodies for detection of the stromylsin-3 protein in a sample.

Antibodies specific for human stromelysin-3 and a method for detection

The present invention relates to a gene encoding a new member of the metalloproteinase family which has been found to be specifically associated with invasive breast cancer, and to methods of diagnosis for such cancer comprising detection of the marker or its nucleotide sequence, and to treatment or prophylaxis by inhibiting, altering the activity of or binding the marker, or by interfering with its synthesis.

Analytical markers for malignant breast cancer

Growing community of inventors

Strasbourg, France

Jean-Pierre Bellocq