Université Grenoble Alpes

Institut National De La Sante Et De La Recherche Medicale

Centre Hospitalier Universitaire Grenoble Alpes

Centre National De La Recherche Scientifique

Centre Hospitalier Universitaire Grenoble

Centre Hospitalier RÉgional De Grenoble

Institut National De La Sante Et De La Recherche Medicale (inserm)

Jean-Pierre Alcaraz

Philippe Cinquin

Donald Keith Martin

Abdelkader Zebda

Jacques Thelu

Bertrand Toussaint

Audrey Le Gouellec

Aziz Bakri

Patrick Tuvignon

Nawel Khalef

Sarra El Ichi

Dominique Schneider

Fabian Reche

Max Maurin

Thomas Soranzo

Jean-Marc Kweter

Sarra El Ichi Ribault

The application relates to a device for collecting a sample of intestinal fluid comprising a polymeric inner material having an at least partially compressed open cell structure, having a volume Vand being suitable for swelling to a volume greater than or equal to 1.1×Vby absorbing intestinal fluid, said material being encased with an elastic polymeric casing impervious to digestive fluid, said casing comprising at least one opening allowing the intake of intestinal fluid into the inner material, a gastro-resistant material suitable for dissolving in intestinal fluid at 37° C. being disposed on top of each opening, and at least one mechanism for closing the opening(s).

Device for collecting intestinal fluid

A device intended to be implanted in a human or animal body, in order to produce hydrogen in situ from molecules present in the body medium in which the device is implanted, this device having an anode and a cathode, which are each electrically connected to a pole of an electrical energy source, and having a semi-permeable material separating the electrodes from the body medium, in which device, when the connection to the electrical energy source is effective in situ, in the presence of body fluid, a closed electrical circuit is formed, with production of hydrogen at the cathode, the semi-permeable material having a cutoff threshold of between 50 and 500 Da.

Implantable device for producing hydrogen

Thermo-electric generator which is intended to be immersed in a fluid which contains at least one chemical species, comprising two electrodes each having a first end and a second end, the first ends being connected to each other, the generator being configured to generate an electrical voltage between the two ends when a temperature difference is imposed between each first end and the corresponding second end, the temperature difference being such that one end, referred to as the 'hot end', of each electrode has a temperature which is strictly greater than the temperature of the other end. The hot end of at least one electrode comprises a micro-organism or an enzyme which is capable of causing at least one exothermic reaction involving the chemical species.

Thermo-electric generator, associated implantable device and method

The device, that can be implanted in the intestinal cavity, comprises a reactor comprising a semi-permeable or porous membrane or coating linked to a element for attachment to an intestinal or gastric wall. The reactor can be in the form of a ribbon, a structure having more than two faces or an open structure delimiting a lumen, comprising, or formed from, a semi-permeable or porous membrane. The reactor can also delimit, at least partially with the semi-permeable or porous membrane of same, a closed inner space. The reactor can comprise or carry enzymes or micro-organisms, in particular bacteria or yeast. The reactor is used for generating a chemical reaction with one or more molecules present in the intestine, or for producing one or more biologically active molecules. It can, in particular, be used for consuming sugars, disaccharides and simple sugars or producing essential amino acids or other molecules having a positive effect on the health.

Implantable intestinal reactor

Growing community of inventors

Pontcharra, France

Jean-Pierre Alcaraz