Centre National De La Recherche Scientifique

Université Paris 13

Assistance Publique-hopitaux De Paris

Institut National De La Sante Et De La Recherche Medicale

UniversitÉ Paris Descartes

UniversitÉ De Paris

Universite Paris Cité

Jean-Philippe Wolf

Morgane Bomsel

Anne Lombes

Christophe Poncelet

Anne LOMBÈS

The present invention relates to the use of a cyclic peptide comprising the tripeptide reproducing a binding site of fertilin beta to the oocyte integrin, for improving cellular energy metabolism. More particularly, the invention concerns the use of a cyclic peptide comprising the tripeptide FEEc for stimulating the energy metabolism of gametes or embryonic cells in the context of medically assisted procreation (MAP) protocols, in particular promoting the in vitro maturation of the oocyte, the fertilization rate and the birth rate.

Use of a cyclic tripeptide for improving cellular energy metabolism

This catheter comprises a tubular catheter body defining a longitudinal channel, the distal end of the catheter body being closed, and the channel opening out through a single side orifice onto an external surface of a side wall of the catheter body at a distance from this distal end. The channel includes a curved distal end segment and has a substantially constant diameter along the entire length thereof.

Catheter, in particular for implanting an embryo in the uterine cavity of a human being or animal, and corresponding instrument

The invention relates to a cyclic peptide increasing the fusiogenic capacity of the oocyte arising from the disintegrin loop of fertilin beta, to a pharmaceutical composition comprising said cyclic peptide and to the use thereof, particularly in order to supplement culture media used to carry out in vitro fertilization.

Peptide increasing fusiogenic capacity of a gamete

Growing community of inventors

Paris, France

Jean-Philippe Wolf