Flamel Technologies

Jean-Philippe Selles

Olga Burguiere

Ahmad Yassine

Gerard Soula

Pierre Autant

The present invention relates to microcapsules for the oral administration of medicinal and/or nutritional active principles (AP), which are smaller than or equal to 1000 .mu.m in size. These microcapsules consist of particles which are coated with a coating material consisting of a mixture of a film-forming polymer derivative, a hydrophobic plasticizer, a functional agent and a nitrogen-containing polymer. These microcapsules are also characterized by their ability to remain in the small intestine for a long time (at least 5 hours) and to allow, during the residence, release and absorption of the AP. The invention also relates to a process for the production of the said microcapsules.

Medicinal and/or nutritional microcapsules for oral administration

The present invention relates to controlled-release microcapsules of acetylsalicylic acid which comprise particles of acetylsalicylic acid with a size of between 100 and 1000 .mu.m, coated with a coating material consisting of a mixture of a cellulosic film-forming polymeric derivative, an antiadherent, a plasticizer, a lubricant and a vinylic film-forming polymeric derivative. The invention further relates to a process for the preparation of said microcapsules.

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Montpellier, France

Jean-Philippe Selles