Evolva Sa

Other

Jean-Philippe Meyer

Prathama Satyendra Mainkar

Alexandra Santana Sorensen

Peteris Alberts

Melya Hughes Crameri

Thierry Bonnaud

Cecil Pace-Asciak

Alexandra SantAna Sorensen

Peter Denim

Joanne Kelleher

David Pearson

Karsten Kristiansen

Alexandra c/o Evolva Sa Santana Sorensen

Specifically useful stereoisomers of 1,3-dioxane derivatives are described and their use in the treatment of a disease or condition dependent on PPAR modulation, such as diabetes, cancer, inflammation, neurodegenerative disorders and infections as well as their use in the treatment of a disease related to TP, such as cardiovascular diseases. 

Substituted 1,3-dioxanes useful as PPAR modulators

The present invention relates to enantiomeric forms of hepoxilin analogs of Formula I-VIII, pharmaceutical compositions thereof, a method for the separation of said enantiomeric forms of hepoxilin analogs comprising applying said hepoxilin to a chiral phase HPLC column and eluting said hepoxilin with an alkane and alcohol solvent mixture. Said enantiomeric forms of hepoxilin analogs of Formula I-VIII were found to be useful in controlling the biological effects of PPAR mediated transcriptional control for the treatment of diseases such as cancer, thromboxane-mediated diseases and for modulating intracellular calcium concentration. 

Hepodxilin analog enantiomers

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Strasbourg, France

Jean-Philippe Meyer