Sanofi

Sanofi-aventis

Sanofi-synthelabo

Jean-Philippe Ducoux

Patrick Gueule

Xavier Emonds-Alt

Vincenzo Proietto

Murielle Rinaldi-Carmona

Francis Barth

Didier Van Broeck

Christian Congy

Nathalie Chabert

Arnaud Rouquette

The invention relates to compounds of the formula (I), where: Ris: a &#x2014;NRRgroup; an unsubstituted or substituted phenyl; Ris: a (C-C)alkyl; an &#x2014;X&#x2014;Rgroup; Rand Reach are independently a substituted phenyl; Ris a hydrogen atom or a (C-C)alkyl; Ris an unsubstituted or substituted (C-C)alkyl; or Rand Rtogether with the nitrogen atom to which they are bonded constitute an unsubstituted or substituted heterocyclic compound; X is a (C-C)alkylene; Ris an &#x2014;ORgroup, a &#x2014;NRRgroup, an &#x2014;SO&#x2014;(C-C)alkyl group; Ris a hydrogen atom or a (C-C)alkyl; Ris a hydrogen atom or a (C-C)alkyl; Ris a hydrogen atom, a &#x2014;CORgroup, an &#x2014;SORgroup or a &#x2014;CO(CH)OH group; Ris an unsubstituted or substituted (C-C)alkyl; m is 1, 2 or 3. The invention also relates to methods for preparing same and to the therapeutic use thereof. 

Derivatives of 3-alkoxy-4,5-diarylthiophene-2-carboxamide, preparation thereof, and therapeutic use thereof

The subject matter of the invention is compounds corresponding to formula (I), in which: Rand R, together with the nitrogen atom to which they are attached, constitute a saturated heterocyclic radical containing from 4 to 7 atoms, which is preferably substituted; one of the two substituents Rand Ris a group Y-A-R; Y is an oxygen atom or an &#x2014;S(O)&#x2014;, or &#x2014;OSOgroup; A is an unsubstituted (C-C) alkylene group; Ris an &#x2014;OR, &#x2014;CH, &#x2014;NRR, &#x2014;CONRR, &#x2014;NRCOR, &#x2014;S(O)R, or &#x2014;NRSORgroup; &#x2014;Ris a hydrogen atom or a (C-C) alkyl group. The present invention also relates to the methods of preparation and the therapeutic uses of the compounds of formula (I). 

Thiophene-2-carboxamide derivatives, preparation thereof and therapeutic use thereof

The subject of the present invention is compounds corresponding to formula (I): Wherein X, R, R, Rand Rare as described herein. The invention also relates to a method for the preparation and application of said compounds as cannabinoid CB1 receptor antagonists.

N-[(4,5-diphenyl-2-thienyl)methyl]amine derivatives, their preparation and their therapeutic application

The invention relates to compounds of formula (I): Wherein X, R, R, Rand Rare as described herein. The invention also relates to a method for preparing the aforementioned compounds and to their therapeutic application.

N-[(4,5-diphenyl-2-thienyl)methyl]sulfonamide derivatives, preparation thereof and their therapeutic application

The invention discloses and claims a compound of formula (I): Wherein R, R, R, R, R, R, R, Rand Rare as defined herein. Further embodiments of the invention include a method of preparation of a compound of formula (I), its pharmaceutical composition and a method of treatment of a disease using a compound of formula (I).

Thiophene-2-carboxamide derivatives, preparation and therapeutic application thereof

The invention relates to the compounds of formula:as well as to the salts thereof with inorganic or organic acids, to solvates thereof and/or to hydrates thereof, which have strong affinity and high selectivity for the human NKreceptors of substance P. The invention also relates to the process for preparing them, to the intermediate compounds of formula (VII) which are useful for the preparation, to pharmaceutical compositions containing them and to their fuse for the manufacture of medicinal products intended for treating any pathology in which substance P and the human NKreceptors are involved.

Piperidine derivatives, process for obtaining them and pharmaceutical compositions containing them

1-Phenacyl-3-phenyl-3-(piperidylethyl)piperidine derivatives, process for the preparation thereof and pharmaceutical compositions containing them

N-(phenylacetyl)morpholine derivatives useful as NK1 receptor antagonists, a process for the preparation thereof, and pharmaceutical compositions containing them as active principle.

Morpholine derivatives, method for the production thereof and pharmaceutical preparations containing said derivatives

Piperidine derivatives, process for obtaining them and pharmaceutical compositions containing them, of formula ##STR1## used as neurokinin receptor antagonists, which are, in particular, useful for the treatment of all substance P- and neurokinin-dependent pathologies.

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Combaillaux, France

Jean-Philippe Ducoux