Roussel Uclaf

Hoechst Aktiengesellschaft

Hoechst Marion Roussel

Jean-Paul Vevert

Michel Fortin

Jidong Zhang

Simone Jouquey

Bertrand Heckmann

Bernward Scholkens

Jacques Guillaume

Gilles Hamon

Hermann J Gerhards

Daniel Frechet

Adalbert Wagner

Jean-Luc Haesslein

Alain Corbier

Jean-Claude Caille

Rainer Henning

Francoise Delevallee

Heinz-Werner Kleemann

Heinrich Christian Englert

Reinhard Becker

Wolfgang Linz

Jean-Claude Gasc

Francis Petit

Stanislas Didierlaurent

Rogert Deraedt

John-Claude Caille

Imidazole n-benzyldioxol derivatives, method for preparing same,

2-alkyl-1H-imidazole-5-carboxylic acids

The invention relates to the use and the products of formula (I): ##STR1## in which: R.sub.1 =represents hydroxyl, alkyl, alkenyl, alkynyl, alkoxy, alkylthio, formyl, cycloalkyl, optionally interrupted by heteroatoms,

Imidazole-5-carboxylic acid compounds

Derivatives of imidazole, their preparation process, the new

Compositions for reducing abnormal stimulation of endothelin receptors

The bicyclic derivatives of pyridines of the formula ##STR1## and their non-toxic, pharmaceutically acceptable salts and a process and intermediates for their preparation which compounds are inhibitors of angiotensin II effects, particularly a vasoconstrictor activity.

Method for inhibiting vasoconstriction

Method of inhibiting angiotensin effects

Azole derivatives, process for their preparation, and their use Azole derivatives of the formula (I) ##STR1## in which A, L, O, R.sup.1, X, Y, Z and q have the meanings given, process for their preparation, pharmaceutical preparations and the use of the compounds are described. Azole derivatives of the formula I where the symbols have for example the following meanings:

Azole derivatives, process for their preparation and their use

Novel pyrimidine derivatives of the formula ##STR1## represents: either a group: ##STR2## or a group: ##STR3## having angiotensin II inhibiting activity.

Pyrimidine derivatives

Imidazoles of the formula ##STR1## and their non-toxic, pharmaceutically acceptable salts with acids and bases having an antagonistic activity against angiotensin II receptors.

Imidazoles and their salts having antagonistic activity to angiotesin II

The invention relates to compounds of the formula ##STR1## in which X, Y and Z are identical or different and are N or CR.sup.2, L is an alkylene radical, q is 0 or 1, and A is the radical of a fused heterobicyclic compound. The invention furthermore relates to a process for preparing the said compounds, agents containing these, and the use thereof for angiotensin II receptors.

Substituted imidazoles

Bicyclic pyridines which are angiotensin II inhibitors

Imidazole derivatives having angiotensin II receptor antagonistic

The invention relates to compounds of the formula I ##STR1## in which X, Y and Z are identical or different and are N or CR.sup.2, R.sup.1 and R.sup.2 are as defined in the description, L is an alkylene radical, q is 0 or 1, and A is the radical of a fused heterobicyclic compound. The invention furthermore relates to a process for preparing the said compounds, agents containing these, and the use thereof in the treatment of high blood pressure.

Substituted imidazoles, pharmaceutical compositions containing these,

Novel imidazoles of the formula ##STR1## and their non-toxic, pharmaceutically acceptable salts with acids and bases having an antagonistic activity against angiotensin II receptors.

Benzimidazole compounds

Growing community of inventors

Pantin, France

Jean-Paul Vevert