Centre National De La Recherche Scientifique

Université De Nantes

Jean-Paul Quintard

Michel Pereyre

Gaelle Kerric

Francoise Zammattio

Erwan Le Grognec

Bernard Elissando

Jean-Mathieu Chretien

Françoise Zammattio

A supported alkoxylated organotin reactant, to the process for preparing same, to the use of such a reactant as a catalyst for heterogeneous-phase organic synthesis, and also to a process for heterogeneous-phase synthesis of 5-substituted or 1,5-disubstituted tetrazoles using such a reactant.

Supported alkoxylated organotin reactant, preparation and use for heterogeneous-phase synthesis of tetrazoles

The invention concerns a method of preparation of aminomethyltriorganotin compounds, preferably .alpha.-mono or disubstituted, the new tin compounds obtained thereby and an application of said tin compounds to the synthesis of aminomethylorganometallic compounds and to the regiospecific preparation of .beta.-aminoalcohols. The intermediate tin and metallic compounds are new. The method for preparing the tin compounds comprises reacting an iminium salt with a corresponding stannylanion, preferably a triorganostannylanion. This method provides best yields and provides regiospecific .beta.-aminoalcohols useful by having in most cases a large spectrum of pharmacological activities.

Aminomethyltriorganotin compounds, preferably .alpha.-mono or

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La Chapelle sur Erdre, France

Jean-Paul Quintard