Choay, S.a.

Dropic - Societe Civile De Gestion De Droits De Propriete Industrielle

Sanofi

Sanofi Sa

Other

Jean-Paul Fournier

Patrick Choay

Pierre M Roger

Claude Monneret

Alain Martin

Robert C Moreau

Jean Choay

Rolande Leroy

The invention relates to nitrosourea derivatives, a process for their preparation and pharmaceutical compositions containing them. The nitrosourea derivatives of the invention correspond to the following formula (I): ##STR1## in which: R can represent a hydrogen atom or an alkyl group from 1 to 30 carbon atoms, X represents a hydroxy group or an -NR.sub.1 R.sub.2 group, Y represents a hydrogen atom, a hydroxy group or an -NR'.sub.1 R'.sub.2 group, where R.sub.1 and/or R'.sub.1 each represent a hydrogen atom or a ##STR2## group, Hal being a halogen, and R.sub.2 and/or R'.sub.2 can each represent a hydrogen atom or an alkyl group comprising from 1 to 6 carbon atoms, R' and R' can represent hydrogen or OH, provided that at least X represents ##STR3## with R.sub.1 representing ##STR4## or Y represents ##STR5## with R'.sub.1 representing ##STR6## and provided that either R' represents hydrogen or R' represents hydrogen, and R' and R' cannot be simultaneously hydrogen atoms. These compounds present an antitumor activity.

Process for preparing nitrosourea derivatives

Sulphonamides derived from diarylmethanes, the processes for preparing

The invention relates to nitrosourea derivatives, a process for their preparation and pharmaceutical compositions containing them. The nitrosourea derivatives of the invention correspond to the following formula (I): ##STR1## in which: R can represent a hydrogen atom or an alkyl group from 1 to 30 carbon atoms, X represents a hydroxy group or an --NR.sub.1 R.sub.2 group, Y represents a hydrogen atom, a hydroxy group or an --NR'.sub.1 R'.sub.2 group, where R.sub.1 and/or R'.sub.1 each represent a hydrogen atom or a ##STR2## group, Hal being a halogen, and R.sub.2 and/or R'.sub.2 can each represent a hydrogen atom or an alkyl group comprising from 1 to 6 carbon atoms, R' and R' can represent hydrogen or OH, provided that at least X represents ##STR3## with R.sub.1 representing ##STR4## or Y represents ##STR5## with R'.sub.1 representing ##STR6## and provided that either R' represents hydrogen or R' represents hydrogen, and R' and R' cannot be simultaneously hydrogen atoms.

Nitrosourea derivatives, process for their preparation and medicaments

The subject of the invention is a novel procedure for the preparation of the compounds of formula I: ##STR1## in which n varies in particular from 2 to 5 and R represents Cl, Br or F

Novel procedure for the preparation of activated nitrosocarbamates

The invention relates to new N-cyclic benzenesulfonamides, their process of preparation and their use as active substance of pharmaceutical compositions. The new benzenesulfonamides according to the invention correspond to the following general formula (I): ##STR1## in which: V represents, for example, hydrogen,

Cyclic benzenesulfonamides, process for their preparation and their use

Pharmaceutical compositions of N-heterocyclic benzenesulfonamides and

The invention relates to new N-substituted benzenesulfonamides, the process for their preparation and their use. The compounds according to the invention correspond to the general formula (I): ##STR1## in which: n and m have values from 0 to 4;

N-substituted 2,4-dialkoxy benzenesulfonamides and pharmaceutical

The invention relates to trisubstituted sulfohalides, the process for their preparation and their use as intermediate products for the manufacture of novel compounds. The trisubstituted sulfohalides according to the invention correspond to the following general formula (I): ##STR1## in which: X is a halogen atom, particularly bromine or preferably chlorine; R.sub.3 and R.sub.4 each represent, independently of one another, a lower alkyl radical having from 1 to 4 carbon atoms, A represents hydrogen, halogen, alkoxy radicals having from 1 to 4 carbon atoms, alkylsulfonyl groups having from 1 to 4 carbon atoms, or the group NO.sub.2, or CF.sub.3. The invention is useful in the manufacture of medicaments.

Substituted 2,4-dialkoxy benzene sulfonyl chlorides

The invention relates to new benzenesulfonyl-lactams, process for their preparation and their use as active substance in pharmaceutical compositions. Compounds according to the invention correspond to the general formula (I): ##STR1## in which: X can represent hydrogen,

Benzenesulfonyl-lactams and their use as active substances of

The invention relates to trisubstituted sulfohalides, the process for their preparation and their use as intermediate products for the manufacture of novel compounds. The trisubstituted sulfohalides according to the invention correspond to the following general formula (I): ##STR1## in which: X is a halogen atom, particularly bromine or preferably chlorine;

Substituted 2,4 dialkoxy benzene sulfonyl chlorides

Amino-4 chloro-5 methoxy-2 N-(N-ethyl methyl-2 pyrrolidino) benzenesulfonamide is a novel compound corresponding to the formula ##STR1## and is prepared by reacting sulfonyl chloride of the formula ##STR2## with the amine of the formula ##STR3## This compound and its addition salts with physiologically acceptable mineral or organic acids, is a useful medicament for the treatment of ulcerous gastro-duodenal disorders.

Novel n-substituted benzenesulfonamide, process for its preparation and

The invention relates to new N-substituted benzenesulphonamides of general formula ##STR1## in which n is 2 or 3,

N-Substituted 2-methoxybenzenesulphonamides, process for preparing them

The invention relates to new N-substituted benzenesulphonamides of general formula ##STR1## in which N IS 2 OR 3,

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Versailles, France

Jean-Paul Fournier