Bristol-myers Squibb Compnay

Bristol-myers Company

Jean-Paul Daris

Alain Martel

Pierre Dextraze

Philippe Lapointe

Jacques Corbeil

Piyasena Hewawasam

Ashvinikumar V Gavai

Edward H Ruediger

Dolatrai M Vyas

Yong-Jin Wu

Carol Bachand

Jie Chen

Harold A Mastalerz

Anne Marinier

Gene G Kinney

Guifen Zhang

Alexandre L'Heureux

Huan He

Steven Dworetzky

Li-Quang Sun

Yong-Jiang Hei

Martel Alain

The present invention provides compounds of formula I and pharmaceutically acceptable salts thereof. The compounds of the invention inhibit tyrosine kinase activity of growth factor receptors such as HER1, HER2 and HER4 thereby making them useful as antiproliferative agents. The compounds are also useful for the treatment of other diseases associated with signal transduction pathways operating through growth factor receptors.

Pyrrolotriazine compounds

Cinnamide derivatives as KCNQ potassium channel modulators

The 5,6-dihydronaphthalenyl derivatives of the formulae

5,6-dihydronaphthalenyl derivatives having retinoid-like activity

A dithioacetal carbapenem of the formula ##STR1## in which R.sup.1 is hydrogen or C.sub.1-6 alkyl;

Antibiotic C-3 dithioacetal-substituted carbapenem compounds,

Disclosed herein is a novel high .beta.-yield producing novel intermediates of the formula ##STR1## where R.sup.4 is ##STR2## useful in the synthesis of 1-.beta.-alkyl carbapenems.

High percentage .beta.-yield synthesis of carbapenem intermediates

Disclosed herein is a novel process using novel silyl enol ether intermediates of the formula ##STR1## to generate novel azetidione thiolester intermediates of the formula ##STR2## which can be used to form 1-.beta.-alkyl carbapenem antibiotics. It has now been discovered that if the R.sup.4 group is selected from a small group of moieties having the formula: ##STR3## an increased .beta.-yield of up to approximately 100% can be obtained.

High percentage beta-yield synthesis of carbapenem intermediates

A novel stereocontrolled process is disclosed for converting 6-aminopenicillanic acid to an optically active azetidinone of the formula ##STR1## wherein R' is a hydroxy-protecting group by use of a 6,6-dihaloanhydropenicillin or 6,6-bis(phenylselenyl)anhydropenicillin intermediate.

Stereocontrolled acetoxyazetidinone process

Anhydropenicillin intermediates

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St-Hubert, Canada

Jean-Paul Daris