Institut Pasteur

Jean P Dedet

Christian P Roussilhon

Jurg Gysin

Serge E Pauillac

Thierry G Fandeur

Philippe Dubois

Luiz H Pereira Da Silav

Luiz P Pereira De Silva

A process for preparing a vaccine against malaria comprising at least one polypeptide extracted from a schizont form of a strain of Plasmodium containing polypeptides antigenic to malaria. The polypeptides are recognized by immunoglobulin from a Saimiri Sciureus monkey resistant to the strain. The process includes the steps of:

Process for preparing a vaccine against malaria

An immunogenic composition for a vaccine against human malaria. The composition contains one or more polypeptides that can be extracted from a schizont form of a human-malaria parasite such as a Plasmodium falciparum. The polypeptides have a molecular weight of 40,000 to 140,000, and they react with protective antibodies which come from a monkey resistant to the malaria parasite and which can, by in vivo transfer to a monkey sensitive to the parasite, protect the sensitive monkey against the parasite.

Polypeptidic fractions inducing protective antibodies against malaria

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Cayenne, France

Jean P Dedet