Adir Et Compagnie

Jean-Michel Rivet

Mark Millan

Jean-Louis Peglion

Bertrand Goument

Gilbert Lavielle

Olivier Muller

Aimee Dessinges

Anne Dekeyne

Bernard Cimetiere

Alain Gobert

Cyano-indole serotonin-reuptake inhibitor compounds

A compound of formula (I): ##STR1## wherein: R.sub.1, R.sub.2 and R.sub.3, which may be the same or different, represent a group as defined in the description,

Benzo[3,4]cyclobuta[1,2-c]pyrrole compounds

New N-substituted N'-heterobicyclic piperazines corresponding to the general formula I: ##STR1## wherein: R represents: ##STR2## D represents a single bond, except when R represents naphthyl, or a hydrocarbon chain having 1 to 8 carbon atoms inclusive which is straight-chain or branched by a gem-dimethyl; and A-B represents: --(CH.sub.2).sub.2 --O--, --(CH.sub.2).sub.3 --O--, or --CO--CH.dbd.CH--, as well as their possible stereoisomers, epimers, and pharmaceutically-acceptable acid addition salts thereof; and medicinal products containing the same, useful in the treatment of a disorder requiring a 5-HT.sub.1A receptor antagonist.

N-substituted N'-heterobicyclic piperazines having pharmaceutical

The compounds are 1,4-disubstituted piperazines useful for the treatment of disorders of central nervous system and neuroendocrine disorders. A compound disclosed is (R,S)-4-(benzodioxan-5-yl)-1-[(benzocyclobutan-1-yl)methyl]piperazine.

1,4-disubstituted piperazines

Growing community of inventors

Nanterre, France

Jean-Michel Rivet