Les Laboratoires Servier

Les Laboratories Servier

Les Laboratories Server

Jean-Michel Lerestif

Jean-Pierre Lecouve

Daniel Brigot

Jean-Claude J Souvie

Maryse Phan

Eric Gojon

Daniel Dron

Jean-Louis Peglion

Aimee Dessinges

Philippe Letellier

Bernard Serkiz

Marina Gaillard

Mathieu Boiret

Loic Meunier

Nicolas Robert

Gerard Damien

Stephane Horvath

Marie-Noelle Auguste

Isaac Gonzalez Blanco

Gérard Damien

Stéphane Horvath

Marie-Noëlle Auguste

Loïc Meunier

Industrial synthesis process for the compound of formula (I): 

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Process for the optical resolution of the compound of formula (I): by chiral chromatography. Application in the synthesis of ivabradine, of its addition salts with a pharmaceutically acceptable acid and of their hydrates.

Process for the resolution of enantiomers of (3,4 dimethoxy-bicyclo[4.2.0]octa-1,3,5-trien-7-yl)nitrile and application in the synthesis of ivabradine

Process for the resolution of enantiomers of (3,4-dimethoxy-bicyclo[4.2.0]octa-1,3,5-trien-7-yl)nitrile and application in the synthesis of ivabradine

Industrial synthesis process for, and crystalline form I of, the compound of formula (I): and also crystalline form I of the associated free base. Medicinal products containing the same which are useful in the treatment of disorders of the histaminergic system.

Process for the resolution of enantiomers of (3,4-dimethoxy-bicyclo[4.2.0]octa-1,3,5-trien-7-yl) nitrile and application in the synthesis of ivabradine

Process for the synthesis of ivabradine of formula (I): and addition salts thereof with a pharmaceutically acceptable acid.

Process for the synthesis of ivabradine and addition salts thereof with a pharmaceutically acceptable acid

Process for the synthesis of the compound of formula (I):  Application in the synthesis of ivabradine, addition salts thereof with a pharmaceutically acceptable acid and hydrates thereof.

Process for the synthesis of 7,8-dimethoxy-1,3-dihydro-2H-3-benzazepin-2-one, and application in the synthesis of ivabradine and addition salts thereof with a pharmaceutically acceptable acid

Process for the synthesis of ivabradine of formula (I): addition salts thereof with a pharmaceutically acceptable acid and hydrates thereof. &#x3b1; crystalline form of ivabradine hydrochloride. Medicinal products containing &#x3b1; crystalline form of ivabradine hydrochloride, which are useful as bradycardics.

Process for the synthesis of ivabradine of formula (I): addition salts with a pharmaceutically acceptable acid and hydrates thereof. &#x3b1; crystalline form of ivabradine hydrochloride. Medicinal products containing the a crystalline form of ivabradine hydrochloride, which are useful as bradycardics.

Process for the synthesis of compounds of formula (I): wherein Rand R, which may be the same or different, each represent a linear or branched (C&#x2013;C)alkoxy group or form, together with the carbon atom carrying them, a 1,3-dioxane, 1,3-dioxolane or 1,3-dioxepane ring. Application in the synthesis of ivabradine, addition salts thereof with a pharmaceutically acceptable acid, and hydrates thereof.

Process for the synthesis of 1,3-dihydro-2H-3-benzazepin-2-one compounds, and to the application thereof in the synthesis of ivabradine and addition salts thereof with a pharmaceutically acceptable acid

Process for the synthesis of 1,3,4,5-tetrahydro-2H-3-benzazepin-2-one compounds, and application in the synthesis of ivabradine and addition salts thereof with a pharmaceutically acceptable acid

Process for the synthesis of the compound of formula (I): Application in the synthesis of ivabradine, addition salts thereof with a pharmaceutically acceptable acid, and hydrates thereof.

Process for the synthesis of (1S)-4,5-dimethoxy-1-(methylaminomethyl)-benzocyclobutane and addition salts thereof, and to the application thereof in the synthesis of ivabradine and addition salts thereof with a pharmaceutically acceptable acid

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Yvetot, France

Jean-Michel Lerestif