Rhone-Poulenc Chimie

Rhone-Poulenc Sante

Rhodia Chimie

Flamel Technologies

Flamel Technologies (Societe Anonyme)

Jean-Michel Grosselin

Philippe Denis

Georges Cordier

Francois Metz

Claude Mercier

Gerard Soula

Catherine Castan

Pierre Fouilloux

Hubert Kempf

Rafael Jorda

Jean-Pierre Lecouve

Laurent Gilbert

Bernard Langlois

Gerard Forat

Jean Jenck

Paul Rouyer

Rosemarie Bailliard

Philippe Delis

A process and reagent for allylating a nucleophile preferably of formula (V).

Allylation reagent and process for allylating a nucleophile

Aerosol composition for forming a hydrated membrane, and applications

Method for the preparation of polyamino acids

The alkyl adipates are prepared by reacting admixture consisting essentially of alkyl 3-pentenoate and alkyl 2-pentenoate with carbon monoxide and an alcohol, at elevated temperature, under superatmospheric pressure and in the presence of a catalytically effective amount of cobalt or a cobalt compound and a nitrogenous heterocyclic base.

Preparation of alkyl adipates

Adipic acid is selectivity prepared by reacting water and carbon monoxide with at least one pentenic acid, in the presence of a catalytically effective amount of an iridium-based catalyst and at least one iodinated promoter therefor at an elevated temperature, at a pressure greater than atmospheric and in at least one solvent medium which comprises a saturated aliphatic or cycloaliphatic hydrocarbon or halogenated derivative thereof, an aromatic hydrocarbon or halogenated derivative thereof, or an aliphatic, aromatic or mixed ether, and wherein the I/Ir atomic ratio is less than 20.

Preparation of adipic acid by hydrocarboxylation of pentenic acids

Adipic acid is prepared by hydrocarboxylating at least one pentenic acid in the presence of a catalytically effective amount of rhodium values, whether metallic rhodium or a compound thereof, and an iodine-containing promoter therefor, as well as in the presence of a cocatalytically effective amount of at least one of iridium, ruthenium, osmium or compound thereof.

Adipic acid is selectively prepared, in good yields, by reacting at least one pentenic acid with water and carbon monoxide, the partial pressure of which, measured at 25.degree. C., being less than or equal to 12 bar, in the presence of a catalytically effective amount of a rhodium-based catalyst and at least one iodine-containing promoter therefor, at a temperature ranging from 100.degree. to 240.degree. C. and at superatmospheric pressure, and in a liquid reaction medium which comprises at least one hydrocarbon or chlorocarbon solvent, whether a saturated aliphatic or cycloaliphatic hydrocarbon, aromatic hydrocarbon or chlorinated derivative thereof.

Preparation of adipic acid by hydrocarbonylation of pentenic acids

Adipic acid is selectively prepared by reacting water and carbon monoxide with at least one pentenic acid, in the presence of an iridium-based catalyst and at least one iodine-containing promoter therefor, at an elevated temperature, at a pressure greater than atmospheric pressure, in a reaction medium comprising at least one saturated aliphatic carboxylic acid, ethylenically unsaturated aliphatic carboxylic acid or aromatic carboxylic acid having not more than 20 carbon atoms, with the I/Ir atomic ratio being less than 10.

Adipic acid is selectively prepared, in good yields, by reacting at least one pentenic acid with water and carbon monoxide, the partial pressure of which, measured at 25.degree. C., being less than or equal to 20 bar, in the presence of a catalytically effective amount of a rhodium-based catalyst and at least one iodine-containing promoter therefor, at a temperature ranging from 100.degree. to 240.degree. C. and at superatmospheric pressure, and in a liquid reaction medium which comprises a saturated aliphatic or aromatic carboxylic acid having up to 20 carbon atoms.

A process for the hydrogenation of halogenonitro-aromatic compounds wherein said compounds are contacted with a nickel-, cobalt- or iron-based catalyst, preferably Raney nickel, and hydrogen in the presence of a sulfur-containing compound. Preferably, the sulfur-containing compound is a sulfoxide or sulfone, and the molar ratio of the sulfur-containing compound to the catalyst ranges from about 1:1 to 10:1.

Process for the hydrogenation of halogenonitro-aromatic compounds in the

A process for the preparation of amino halogeno aromatic compounds, according to which a halogenonitro-aromatic compound is brought into the presence of a nickel-, cobalt- or iron-based catalyst, preferably nickel-based, and, more preferably, Raney nickel, in the presence of an effective amount of iodide, at a temperature and hydrogen pressure sufficient to form said halogenoamino-aromatic compound.

This invention relates to a process for preparing an optically active 2-arylpropionic acid of general formula (I), by the hydrogenation, in a heterogeneous aqueous-organic medium, of a 2-arylacrylic acid of general formula (II) in the presence of a catalyst consisting of a rhodium derivative and a water-soluble chiral ligand. In the general formulae (I) and (II), Ar represents an optionally substituted monocyclic or polycyclic aromatic radical or an optionally substituted aromatic heterocyclic radical: ##STR1##

Process for preparing optically active 2-arylpropionic acids

This invention relates to a process for preparation of a platinum-cobalt bi-metallic catalyst having an alloy structure.

Process for the preparation of a catalyst

Saturated aldehydes are prepared by hydrogenation of .alpha.,.beta.-unsaturated aldehydes in a two-phase medium in the presence of a catalyst consisting of a rhodium derivative combined with a water-soluble ligand or of a rhodium complex with a water-soluble ligand.

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Francheville, France

Jean-Michel Grosselin