Anaconda Pharma

Vaxart, Inc.

Aviragen Therapeutics, Inc.

Jean-Michel Gauthier

Marta Blumenfeld

Delphine Compere

The present disclosure is directed to antiviral compounds directed against the papilloma virus, to pharmaceutical compositions containing them, to their preparation method and synthesis intermediates, as well as to their use for treating or preventing an infection by the papilloma virus. The present method thus provides an efficient way of treating patients that have lesions associated with an infection by the papilloma virus.

Piperidine derivatives as human papilloma virus inhibitors

HPV inhibitors with formula (I) where Grepresents a hydrocarbonated bond or chain possibly substituted by one or two alkyl groups, Grepresents a group (see formula Ia+Ib) or R represents a hydrogen, an alkyl, halogenoalkyl, or a prodrug radical such as carbamate, acetyl or dialkylaminomethy, G represents a bond or a hydrocarbonated chain possibly substituted by one or two alkyls, W represents an oxygen or sulphur, Rand Reach represent a group chosen from among hydrogen, halogen, hydroxyl, thio, alkoxy, halogenoalkoxy, alkylthis, halogenoalkylthio, amino, monoalkylamino, dialkylamino, cycloalkyl, alkyl or halogenoalkyl, R3 represents an acid or a prodrug radical of the acid function or a bioisotere of the acid function, A represents an aryl, cycloalkyl, cycloalkenyl or a heterocycle with 6 chains, each possibly substituted, and pharmaceutically acceptable salts.

HPV inhibitors of formula (I) in which Gis &#x2014;NHCO(CH)n-, where n is an integer between 1 and 4, R3 is &#x2014;CW(CH)&#x2014;NR4R5 or &#x2014;CW(CH)CHor &#x2014;CN, where W is O, S or NH and m is an integer between 0 and 5, or R3 is one of the following groups: and A is an optionally substituted aryl group and B is an aryl group, preferably a phenyl which is substituted. 

Human papilloma virus inhibitors and pharmaceutical compositions containing same

HPV inhibitors with formula (I) where Grepresents a hydrocarbonated bond or chain possibly substituted by one or two alkyl groups, Grepresents a group (see formula Ia+Ib) or R represents a hydrogen, an alkyl, halogenoalkyl, or a prodrug radical such as carbamate, acetyl or dialkylaminomethyl, G represents a bond or a hydrocarbonated chain possibly substituted by one or two alkyls, W represents an oxygen or sulphur, Rand Reach represent a group chosen from among hydrogen, halogen, hydroxyl, thio, alkoxy, halogenoalkoxy, alkylthio, halogenoalkylthio, amino, monoalkylamino, dialkylamino, cycloalkyl, alkyl or halogenoalkyl, Rrepresents an acid or a prodrug radical of the acid function or a bioisostere of the acid function, A represents an aryl, cycloalkyl, cycloalkenyl or a heterocycle, each possibly substituted, and B represents an aryl or a heterocycle with 6 chains, each possibly substituted, and pharmaceutically acceptable salts. 

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Conflans-Sainte-Honorine, France

Jean-Michel Gauthier