Centre National De La Recherche Scientifique

Université De Nantes

Graftys

Institut National De La Sante Et De La Recherche Medicale

Oniris

University De Nantes

Graftys Sa

Ecole Nationale Veterinaire Agroalimentaire Et De L'alimentation Nantes Atlantique

Jean-Michel Bouler

Bruno Bujoli

Pascal Janvier

Ibrahim Khairoun

Charlotte Mellier

Verena Schnitzler

Guy Daculsi

Jérôme Guicheux

Olivier Gauthier

Jean-Noël Argenson

Solen Josse

Pierre Weiss

A bone cement paste containing a powder component comprising &#x3b1;-tricalcium phosphate (&#x3b1;-TCP) particles having an average size greater than or equal to 9 &#x3bc;m, and a liquid component comprising blood is disclosed. A method for preparation of the phosphocalcic cement composition is also disclosed.

Phosphocalcic cement composition comprising blood

A method for promoting spine fusion inside intersomatic cages, comprising placing a fusion cage between two vertebral bodies, and injecting a bone cement paste inside said fusion cage, said bone cement paste containing a powder component comprising &#x3b1;-tricalcium phosphate (&#x3b1;-TCP) particles having an average size greater than or equal to 9 &#x3bc;m, and a liquid component comprising blood.

The present invention relates to a macroporous, resorbable and injectable apatitic calcium-phosphate cement with a high compressive strength useful as bone cement and releasing a bone resorption inhibitor, preparation method and uses thereof.

Injectable calcium-phosphate cement releasing a bone resorption inhibitor

The present invention is directed to a novel cement powder comprising an organic component consisting of one or more biocompatible and bioresorbable polymers and an inorganic component consisting of one or more calcium phosphate compounds. The invention also relates to the apatitic CPC resulting from the mixing of said cement powder with a liquid phase and setting.

Macroporous and highly resorbable apatitic calcium-phosphate cement

The present invention relates to a gallium-doped phosphocalcic compound of formula (I):CaGa(PO)&#x2003;&#x2003;(I) The invention further relates to a solid state process and a process in solution for the manufacture of such compounds and the use thereof for the preparation of a biomaterial, in particular a self-setting calcium-phosphate cement (CPC).

Gallium-doped phosphocalcic compounds

The present invention relates to a galliated calcium-phosphate biomaterial comprising a gallium-doped phosphocalcic compound of formula (I):CaGa(PO)&#x2003;&#x2003;(I)wherein 0&#x3c;x&#x3c;1 and the salts, hydrates and mixtures thereof and/or a calcium deficient apatite structure with in particular a (Ca+Ga)/P molar ratio in the range of 1.3 to 1.67, and a gallium content up to 4.5% by weight. It also relates to processes of preparation of such materials and uses thereof, in particular as dental or bony implants. It further relates to a kit comprising a galliated calcium-phosphate biomaterial in combination with a fluid component. It finally relates to methods of use of the galliated calcium-phosphate biomaterial, notably for III) ions increase radio-opacity after bone implantation and can be released for inhibiting bone resorption.

Galliated calcium phosphate biomaterials

A phosphocalcic compound modified by a gem-bisphosphonic acid or one of its salts, a method for preparing same, as well as its use for preparing an injectable composition. The modified phosphocalcic compound is obtained by adding a gem-bisphosphonic acid or one of its alkali metal or alkaline earth salts to a suspension of a precursor phosphocalcic compound in ultras-pure water, while stirring the reaction medium at room temperature, then in recovering by centrifuging the formed compound. The compound is useful for making an injectable composition, for use in the treatment of bone remodeling equilibrium.

Modified phosphocalcic compound, injectable composition containing same

The invention concerns a phosphocalcic compound modified by a gem-bisphosphonic acid or one of its salts, a method for preparing same, as well as its use for preparing an injectable composition. The modified phosphocalcic compound is obtained by adding a gem-bisphosphonic acid or one of its alkali metal or alkaline earth salts to a suspension of a precursor phosphocalcic compound in ultra-pure water, while stirring the reaction medium at room temperature, then in recovering by centrifuging the formed compound. Said compound is useful for making an injectable composition, for use in the treatment of bone remodeling equilibrium.

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Carquefou, France

Jean-Michel Bouler