Centre International De Recherches Dermatologiques Galderma

Centre International De Recherches Dermatologiques C.i.r.d.

Galderma Research & Development

Galderma Research & Development Snc

Centre International De Recherches Dermatologiques Galderma (cird

Centre International De Recherches Dermatologiques

C.i.r.d. Galderma

Centre International De Recherche Dermatologiques Galderma (c.i.r.d.) Galderma

Centre Internationale De Recherches Dermatologiques (c.i.r.d.)

Centre International De Recherches Dermatologioues (cird)

Centre Int'l. De Recherches Dermatologiques Galderma

Centre International De Recherches Dematologiques Galderma (cird

Centre International De Recherches Dermatologiquies Galderma

Centre International De Recherches Dermatologiques (cird Galderma)

Centre International De Recherches Dermatogologiques (c.i.r.d.)

Jean-Michel Bernardon

Braham Shroot

Jacques Eustache

Philippe Nedoncelle

William R Pilgrim

Philippe Diaz

Bruno Charpentier

Oliver Watts

Laurence Clary

Eric Terranova

Simon Trouille

Thibaud Biadatti

Laurence Vigne

Jean-Philippe Rocher

Jean-Phillippe Rocher

Willliam R Pilgrim

Bruno Charpenter

Novel vitamin D analogs, markedly active in the fields of cell proliferation and differentiation, are selected from among (4E,6E)-7-{3-[2-(3,4-bis-hydroxymethylphenyl)-ethyl]phenyl}-3-ethylnona-4,6-dien-3-ol, (E)-6-[3-(3,4-bis-hydroxymethylbenzyloxy)phenyl]1,1,1-trifluoro-2-trifluoromethyloct-5-en-3-yn-2-ol, (3E,5E)-6-[3-(3,4-bis-hydroxymethylbenzyloxy)-phenyl]-1,1,1-trifluoro-2-trifluoromethylocta-3,5-dien-2-ol, (E)-6-{3-[2-(3,4-bis-hydroxymethylphenyl)ethyl]phenyl}-1,1,1-trifluoro-2-trifluoromethyloct-5-en-3-yn-2-ol, and (3E,5E)-6-{3-[2-(3,4-bis-hydroxymethylphenyl)-ethyl]phenyl-1,1,1-trifluoro-2-trifluoromethylocta-3,5-dien-2-ol, and the geometric isomers thereof and these compounds in which one or more of the hydroxyl functions are protected by a protective group &#x2014;(C&#x2550;O)&#x2014;R, in which R is a linear or branched alkyl radical having from 1 to 6 carbon atoms, an aryl radical having from 6 to 10 carbon atoms, or an aralkyl radical having from 7 to 11 carbon atoms, the aryl radical or the aralkyl radical optionally being mono- or disubstituted by a hydroxy group, an alkoxy radical having from 1 to 3 carbon atoms, a halogen atom, a nitro function or by an amino function, and mixtures thereof.

Vitamin D analogs

Novel pharmaceutical/cosmetic compositions contain at least one biaromatic ligand activator of a PPAR&#x3b3; receptor, such biaromatic ligand having the structural formula (I): and are well suited, inter alia, for regulating and/or restoring skin lipid metabolism, for treating a wide variety of dermatological afflictions, and for preventing and/or treating the signs of aging and/or dry skin.

Biaromatic ligand activators of PPAR&#x3b3; receptors

Compounds of formula (I): in which: These compounds can be used in particular in the treatment of dermatological complaints associated with a keratinization disorder, and for combating ageing of the skin.

Biphenyl derivatives substituted with an aromatic or heteroaromatic radical, and pharmaceutical and cosmetic compositions containing them

The invention relates to novel stilbene compounds having the general formula (I):as well as to pharmaceutical compositions for use in human or veterinary medicine, including dermatological, rheumatic, respiratory, cardiovascular and ophthalmic conditions and cosmetic compositions and methods of use thereof.

Stilbene compounds comprising an adamantyl group, compositions and methods thereof

Novel pharmaceutically/cosmetically-active bicyclic aromatic compounds having the structural formula (I):in which Aris a radical having one of the structural formulae (a)-(c):and Ar, X, R, R, R, R, R, R, R, Rand Rare as defined in the specification.

Bicyclic aromatic compounds and pharmaceutical/cosmetic compositions comprised thereof

The invention relates, as novel and useful industrial products, to triaromatic compounds, which are vitamin D analogues, of general formula (I):and also to a method for preparing them and to their use in pharmaceutical compositions intended for use in human or veterinary medicine, or alternatively in cosmetic compositions.

Triaromatic vitamin D analogues

The invention relates to novel heteroethynylenic compounds having the general formula (I):as well as to the use of these compounds in pharmaceutical compositions intended for use in human or veterinary medicine (dermatological, rheumatic, respiratory, cardiovascular and ophthalmological complaints in particular), or alternatively in cosmetic compositions.

Heteroethynylenic compounds and pharmaceutical and cosmetic compositions containing them

Novel pharmaceutical/cosmetic compositions contain at least one biaromatic ligand activator of a PPAR&#x3b3; receptor, such biaromatic ligand having the structural formula (I):and are well suited, inter alia, for regulating and/or restoring skin lipid metabolism, for treating a wide variety of dermatological afflictions, and for preventing and/or treating the signs of aging and/or dry skin.

The invention concerns bi-aromatic compounds of formula (I) in which Ar represents (a), Z being O or S, Ris CH, &#x2014;CH&#x2014;O&#x2014;R, &#x2014;ORor &#x2014;COR; Ris &#x2014;OR, &#x2014;SRor a polyether radical if in the latter case Ris C-Calkyl and is in ortho or meta position relative to X&#x2014;Ar; Ris alkyl or Rand Rtogether form a cycle optionally interrupted by O or S; Ris aryl radical; Ris H, halogen, C-Calkyl or &#x2014;OR; Ris H, alkyl or &#x2014;COR; Ris H, alkyl, &#x2014;N(r')(r&#x2033;) or &#x2014;OR; Ris H, alkyl or &#x2014;COR; Ris alkyl; Ris H, C-Calkyl, alkenyl, monohydroxyalkyl or polyhydroxyalkyl, aryl or aralkyl or a sugar residue, r&#x2032; and r&#x2033; are H, alkyl mono- or polyhydroxyalkyl, aryl, an amino acid or sugar residue or together form a heterocycle, X represents a radical of formula (d) or (e) in which Ris H or &#x2014;OR; Ris H or alkyl; or Rand Rform an oxo radical, and the salts, optical and geometrical isomers of the compounds of formula (I).

Biaromatic compounds and pharmaceutical and cosmetic compositions comprising them

Vitamin D analogues

Bicyclic aromatic compounds

Bi-aromatic compounds linked via a heteroethynylene radical are provided along with pharmaceutical and cosmetic compositions containing these compounds and methods for their use.

Bi-aromatic compounds linked via a heteroethylene radical, and pharmaceutical and cosmetic compositions using them

Growing community of inventors

Le Rouret, France

Jean-Michel Bernardon