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Zentaris Ag

Fournier Industrie Et Sante

Æterna Zentaris Gmbh

Propeptide

Jean Martinez

Jean-Alain Fehrentz

Vincent Guerlavais

Christophe Thurieau

Pierre Dodey

Jean-Michel Luccarini

Jose Antonio Camara Y Ferrer

Isabelle Daffix

Muriel Amblard

Philippe-Francois Winternitz

Catherine Goz&eacute;

Albert Loffet

Gilbert Berg&eacute;

The invention relates to compounds of formula I which are useful for elevating the plasma level of growth hormone in a mammal as well as for the treatment of growth hormone secretion deficiency, growth retardation in child and metabolic disorders associated with growth hormone secretion deficiency.

Growth hormone secretagogues

The invention relates to compounds of formula Iwhich are useful for elevating the plasma level of growth hormone in a mammal as well for the treatment of growth hormone secretion deficiency, growth retardation in child and metabolic disorders associated with growth hormone secretion deficiency.

Rational selection of putative peptides from identified nucleotide, or peptide sequences, of unknown function

Peptide agonists of bradykinin B2 receptor

The invention relates to a process for the preparation of 5-(1-hydroxy-2-urethanethylidene)-2,2-dimethyl-1,3-dioxane-4,6-dione derivatives, which are precursors of chiral tetramic acid derivatives. According to this process, an N-urethane-protected .alpha.-amino acid N-carboxy-anhydride is reacted with Meldrum's acid in an inert organic solvent medium in the presence of a tertiary amine. This process makes it possible to conserve the chirality of the starting material and in particular to simplify the synthesis of 4-amino-3-hydroxy acids and the derivatives thereof via the tetramic acid route.

Process for the stereospecific preparation of

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Saussan, France

Jean Martinez