Biomerieux, Inc.

Jean-Marie Tiercy

Bernard F Mandrand

Bernard Francois Mach

Philippe Cros

Bruno Mougin

Patrice A Allibert

A patient's genetic predisposition to a disease may be analyzed by placing, in the presence of probes, at least one type of amplicon, derived from the amplification of at least one polymorphic region of nucleic acid from the patient. The polymorphic region is a polymorphic region of interest with respect to the disease(s) being sought. The probes include at least one specific 'low-resolution' typing probe that has the ability to hybridize to the polymorphic region of interest of at least one gene or a group of alleles of this gene carried by the amplicon and associated with the disease(s); and at least one specific 'high-resolution' subtyping probe that has the ability to hybridize to the polymorphic region of interest of the allele or of the group of alleles specific for the &#x201c;low-resolution&#x201d; typing probe, the high-resolution probe(s) making it possible to distinguish the allele(s) associated with susceptibility and/or the allele(s) associated with resistance to the disease(s), according to whether or not they hybridize.

Method for analyzing a patient's genetic prediposition to at least one disease and amplification adapted to such a method

A set of probes for determining HLA-DR types or sub-types includes at least one of the following probes:

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Chenes bou Geries, Switzerland

Jean-Marie Tiercy