Synthelabo

Jean-Marie Louis Roger

Philippe Michel Manoury

Henry Najer

Don Pierre Giudicelli

The invention provides novel phenylacetic acid derivatives of the formula: ##STR1## in which X and Y are the same or different and each represents halogen and R represents hydroxyl, alkoxy of 1 to 4 carbon atoms, a radical of formula R.sub.1 --NH--C.sub.n H.sub.2n --O--, in which n is an integer from 1 to 4 and R.sub.1 is hydrogen or an alkanoyl radical R.sub.2 CO--, in which R.sub.2 is alkyl of 1 to 4 carbon atoms, a radical of formula R.sub.4 NH--, in which R.sub.4 is hydrogen or --C.sub.m H.sub.2m OH, where m is an integer from 1 to 3, or a radical of formula: ##STR2## --OC.sub.m H.sub.2m --COOR.sub.2 or --O(CH.sub.2).sub.p --Z radical, where n, m and R.sub.2 have the meanings given above, p is 0 or 1, and Z is a saturated or unsaturated ring with 6 ring atoms, one of which can be nitrogen, and which can carry from 1 to 3 methyl radicals, and the addition salts which such a derivative which contains a salifiable basic group forms with pharmaceutically acceptable acids and a process for their preparation. These compounds are useful as hypolipaemic and hypocholesterolaemic agents.

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Fontenay-aux-Roses, France

Jean-Marie Louis Roger