Centre National De La Recherche Scientifique

Institut National Des Sciences Appliquees De Toulouse

Institut National Recherche Pour L'agriculture, L'alimentation Et L'environement

Institut National De La Recherche Agronomique

Dendris

Institut National Des Science Appliquees - Insa

Jean-Marie Francois

Thomas Walther

Yvan Cam

Ceren Alkim

Cléa Lachaux

Childerick Severac

Julie Foncy

The present invention relates to a recombinant microorganism which exhibits i) a conversion activity from D-ribulose-5-phosphate into D-arabinose-5-phosphate, increased in comparison with the same, non-modified microorganism; ii) a cleavage catalysis activity from D-arabinose-5-phosphate into D-glyceraldehyde-3-phosphate and glycolaldehyde, increased in comparison with the same, non-modified microorganism; iii) an oxidation activity from glycolaldehyde into glycolate, increased in comparison with the same, non-modified microorganism; and iv) an oxidation activity from glyceraldehyde-3-phosphate into 1,3-bisphosphoglycerate, decreased in comparison with the same, non-modified microorganism. The present invention also relates to a process for preparing glycolic acid from pentoses and/or hexoses, using such a recombinant microorganism. The present invention also relates to a process for producing glycolic acid involving a biomass production phase and a bioconversion phase from hexoses and/or pentoses into glycolic acid.

Microorganisms and process for producing glycolic acid from pentoses and hexoses

Growing community of inventors

Plaisance du Touch, France

Jean-Marie Francois