Abbott Laboratories Corporation

Other

Jean-Marc Roch

James P Sullivan

Murali Gopalakrishnan

Clark A Briggs

Edward B Touma

Lisa M Monteggia

David G Mc Kenna

David G McKenna

Victoria E S Scott

Kristi L Anderson

A variant human &#x3b1;7 nicotinic acetylcholine receptor (nAChR) polypeptide is provided wherein the variant contains an amino acid substitution at the valine-274 position of the wild-type human &#x3b1;7 nAChR. Nucleic acid molecules encoding the variant human &#x3b1;7 nAChR, vectors and host cells containing such nucleic acid molecules are also provided. In addition, methods are provided for producing the variant as are methods of using such variants for screening compounds for activity at the nAChR.

Variant human &#x3b1;7 acetylcholine receptor subunit, and methods of production and use thereof

The present invention provides an isolated or purified polynucleotide that encodes human endosulfine polypeptide. Isoforms of human endosulfine are also disclosed. The invention also provides methods of making recombinant human endosulfine using the polynucleotides and host cells transformed with the polynucleotides.

Human endosulfine gene

A variant human &agr;7 nicotinic acetylcholine receptor (nAChR) polypeptide is provided wherein the variant contains an amino acid substitution at the valine-274 position of the wild-type human &agr;7 nAChR. Nucleic acid molecules encoding the variant human &agr;7 nAChR, vectors and host cells containing such nucleic acid molecules are also provided. In addition, methods are provided for producing the variant as are methods of using such variants for screening compounds for activity at the nAChR.

Variant human &agr;7 acetylcholine receptor subunit, and methods of production and use thereof

A variant human &agr;7 nicotinic acetylcholine receptor (nAChR) polypeptide is provided wherein the variant contains an amino acid substitution at the valine-274 position of the wild-type human &agr;7 nAChR. Nucleic acid molecules encoding the variant human &agr;7 nAChR, receptors and host cells containing such nucleic acid molecules are also provided. In addition, methods are provided for producing the variant as are methods of using such variants for screening compounds for activity at the nAChR.

Variant human &agr;7 acetylcholine receptor subunit, and methods of production and uses thereof

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Waukegan, IL, United States of America

Jean-Marc Roch