Centre National De La Recherche Scientifique

Societe De Conseils De Recherches Et D'applications Scientifiques (s.c.r.a.s.)

Societe D'expansion Scientifique Expansia

Jean-Marc Kamenka

Alain Privat

Pierre Bernard D'Arbigny

Jacques Vignon

Guy Lallement

Robert Chicheportiche

Jean-Bernard Cazaux

Eric Manginot

Jacques Hamon

Michel Dafniet

Gerard Barbanel

Jean Costentin

Isoline Caubere

Gerard Rondouin

Martine Michaud

Marie-Jeanne Drian

A method of inhibiting effects of exogenous neurotoxic or neurotoxinic products in warm-blooded animals comprising administering to warm-blooded animals before exposure to said products an inhibitorily effective amount of reversible cholinesterase inhibitor selected from the group consisting of pyridostigmine and physostigmine followed by administration of an inhibitorily effective amount of 2-methyl-1-(1-piperidinyl)-1-(2-thienyl)-cyclohexane in substantially pure racemic, diastereoisomeric or enantiomeric form.

Therapeutic use of a thienylcyclohexylamine derivative

Compound for preparing medicines for treating pathologies involving extracellular glutamate, and methods for obtaining same

The invention concerns novel phenylcyclidine derivatives with selective affinity for low affinity receptors, methods for preparing them, pharmaceutical compositions containing them and their use as protective agents for central or peripheral nervous system cells against acute or chronic degeneration, or as an anticonvulsant.

Phencyclidine derivatives, preparation method and pharmaceutical compositions containing same

A method of inhibiting effects of neurotoxic products in warm-blooded animals comprising administering to warm-blooded animals an amount of 2-methyl-1-(1-piperidinyl)-1-(2-thienyl)-cyclohexane in substantially pure racemic, diastereoisomeric or enantiomeric form effect to inhibit effects of neurotropic products and mixtures of thienyl cyclohexylamine and at least one member of the group consisting of anticholinergic, anticonvulsant or cholinesterase-reactivating substances.

Therapeutic application of a thienycyclohexylamine derivative

Thienylcyclohexane derivatives for thienylcyclohexyl synthesis

The invention relates to pharmaceutical compositions for neuroprotection containing the compound (1S,2R) 1-[1-(2-thienyl)-2-alkylcyclohexyl]piperidine or (1S,2R) 1-[1-(2-furanyl)-2-alkylcyclohexyl]piperdine, or their pharmaceutically acceptable salts. The synthesis and method separation of racemic mixtures to provide pure enantiomers is presented. The compositions have use in the treatment of stroke, CNS trauma and Alzheimer's disease.

Neuroprotective pharmaceutical composition containing stereoisomers of

The invention relates to substituted arylamines and heteroarylamines, their preparation process and the pharmaceutical composition containing them. Said substituted amine is in accordance with the formula: ##STR1## in which R.sup.1 and R.sup.2 are optionally substituted alkyl radicals or form with N an optionally substituted piperazine or piperidine cycle, R.sup.3 and R.sup.4 represent a hydrogen atom or an organic radical, Y represents CR.sup.6 or N and R.sup.5 is an optionally substituted benzothiophenyl, benzofuranyl or naphthyl radical. These amines can be used in pharmaceutical compositions for the treatment of nervous depression or for stimulating vigilance.

Substituted cyclic amines and pharmaceutical composition containing them

Pharmaceutical compositions for neuroprotection containing

Growing community of inventors

Montpellier, France

Jean-Marc Kamenka