Sanofi

Sanofi-aventis

Sanofi-synthelabo

Elf Sanofi

Jean-Marc Herbert

Alain Badorc

Gerard Valette

Andre Bernat

Marie-Francoise Bordes

Francoise Bono

Nathalie Guillo

Pierre Savi

Dino Nisato

Maurice Petitou

Jean-Pierre Maffrand

Jean Wagnon

Daniel Frehel

Bernard Tonnerre

Philippe Duchaussoy

Victor Dos Santos

Françoise Bono

Michaël Bosch

Pierre P Chatelain

Paul De Cointet

Chantal Alcouffe

Philip Janiak

Jean-Pierre Cazenave

Andr&eacute; Bernat

Mich&egrave;le Arnone

Ghislain Defreyn

Mohammed Bensaid

Gilles Kieffer

Denis Delebass Ee

Andr E Bernat

Marie-Francedillaoise Bordes

The present invention relates to novel synthetic polysaccharides with antithrombotic activity exhibiting at least one covalent bond with biotin or a biotin derivative and to a process employing avidin or streptavidin which makes it possible to neutralize these polysaccharides.

Polysaccharides with antithrombotic activity comprising at least one covalent bond with biotin or a biotin derivative

The present invention relates to novel 1,2,3-substituted indolizine derivative which are inhibitors of fibroblast growth factors, to methods or preparing such derivatives, to pharmaceutical compositions comprising such derivatives, and to methods of treatment comprising such derivatives.

1,2,3-substituted indolizine derivatives, inhibitors of FGFs, method for preparing them and pharmaceutical compositions containing them

This invention relates to use of a pyrazole-derived compound that is an antagonist of cannabinoid CBreceptors, alone or in combination with another active ingredient, for preparing medicinal products that are of use in the prevention and treatment of kidney diseases.

Use of a pyrazole derivative for preparing medicines useful for treating renal diseases

The invention is directed to a compound of formula I, wherein R, R, R, Rand Rare as defined herein, or a pharmaceutically acceptable salt thereof, and its pharmaceutically composition, preparation and uses as an inhibitor of FGFs (fibroblast growth factors).

Substituted indolizine 1,2,3,6,7,8 derivatives, FGFs inhibitors, a method for the preparation thereof and pharmaceutical compositions containing said derivatives

The invention relates to substituted 1-piperazinylacylpiperidine derivatives of general formula (I)  

Piperazinylacylpiperidine derivatives, their preparation and therapeutic use thereof

Compounds of formula I or salts thereof: in which

1,2,3-substituted indolizine derivatives, inhibitors of fgfs, method for making same and pharmaceutical compositions containing same

The invention relates to substituted 1-piperazinylacylpiperidine derivatives of general formula (I) in which:  Preparation process and therapeutic application.

Polysaccharides with antithrombotic activity comprising at least a covalent bond with biotin or a biotin derivative

The invention relates to the use of &bgr;,-adrenergic receptor agonists for the preparation of healing drugs and to the pharmaceutical compositions for said use.

Use of agonists of adrenergic &bgr;-3 receptors for preparing wound-healing medicines

The invention relates to compounds of formula: ##STR1## in which: A is selected from O or S; B is selected from C or N;

Heterocyclic derivatives, process for their preparation and their

The invention relates to compounds of formula: ##STR1## in which: A is selected from 0 or S; B is selected from C or N; Z.sub.1 is selected from C.sub.1 -C.sub.4 alkylene or phenylene; Z.sub.2 is C.sub.1 -C.sub.4 alkylene; W is NR.sub.1 R.sub.2, in which R.sub.1 is selected from H or C.sub.1 -C.sub.4 alkyl and R.sub.2 is selected from H, C.sub.1 -C.sub.4 alkyl, CONQ.sub.1 Q.sub.2 or CSNQ.sub.1 Q.sub.2 in which Q.sub.1 and Q.sub.2 are independently selected from H or C.sub.1 -C.sub.4 alkyl, SO.sub.2 Q.sub.3 or COQ.sub.3 in which Q.sub.3 is C.sub.1 -C.sub.4 alkyl, COOQ.sub.4 in which Q.sub.4 is selected from C.sub.1 -C.sub.4 alkyl or benzyl, or R.sub.1 and R.sub.2 taken together with N form a saturated heterocycle, or W is selected from C.sub.1 -C.sub.4 alkoxy or thioalkoxy, CONQ.sub.1 Q.sub.2 or CSNQ.sub.1 Q.sub.2, pyridyl, imidazolyl or COOQ.sub.5 in which Q.sub.5 is C.sub.1 -C.sub.5 alkyl; R.sub.3 is not present when B is N, or is H, C.sub.1 -C.sub.8 alkyl or halogen; Ar.sub.1 is selected from optionally substituted phenyl, thienyl, furyl, indolyl, naphthyl or benzyl or Ar.sub.1 and R.sub.3 taken together form a phenylalkylene group; Ar.sub.2 is selected from pyrimidinyl, quinolyl, isoquinolyl, indolyl, isoindolyl or pyridyl, optionally substituted; as well as their salts.

Heterocyclic derivatives process for their preparation and their

The invention concerns compounds of formula ##STR1## in which R, A, R.sub.1 and Y are as defined in claim 1. The instant compounds have an affinity for the fibrinogen receptor: the complex of the glycoproteins IIb/llIa (GP IIb/IIIa); more particularly, the subject of the present invention is new inhibitors of platelet aggregation which are antagonists of the GP IIb/IIIa receptors, of nonpeptide structure, which are active via the parenteral and oral routes.

Substituted 4-phenylthiazole derivatives, process for their preparation

The invention relates to a new method for the secondary prevention of ischemic events comprising administering to a man in need thereof a therapeutically effective amount of a compound selected from clopidogrel and its pharmaceutically acceptable acid addition salts in association with a pharmaceutically acceptable carrier.

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Tournefeuille, France

Jean-Marc Herbert