Bioalliance Pharma

Pierre Fabre Medicament

Carl Zeiss Meditec Gmbh

Laboratoires Thea

Bioalliance Pharma Sa

Ioltechnologie-production

Disphar International Bv

Laboratoires Cilag

Dow Corning France

Jean-Marc Aiache

Dominique Costantini

Philippe Tourrette

Christine Chaumont

Gilbert Serpin

Said El Meski

Jim Appino

Jo&euml;l Bougaret

Saïd El Meski

Marie Di Battista

Francois Jean-Louis Jerome Boutignon

Thomas Jean Henri Barres

Florian Tapissier

Pascale Gauthier

A solid dosage form for the ocular administration of an active principle includes at least one biocompatible, water-soluble excipient for ophthalmic use. The form is obtained using a method which is selected from among the following: direct compression, dry compression, wet compression, compression of a lyophilizate, the compression being carried out a temperature below 45&#xb0; C., or lyophilization, such that the form can disintegrate and release the active principle in the conjunctival sac. The invention also relates to an ophthalmic insert having the aforementioned dosage form which is appropriately dimensioned for ocular administration.

Solid dosage form for the ocular administration of an active principle, a soluble, solid ophthalmic insert and the production method thereof

The present invention concerns a prolonged release bioadhesive mucosal therapeutic system containing at least one active principle, with an active principle dissolution test of more than 70% over 8 hours and to a method for its preparation. Said bioadhesive therapeutic system comprises quantities of natural proteins representing at least 50% by weight of active principle and at least 20% by weight of said tablet, between 10% and 20% of a hydrophilic polymer, and compression excipients, and comprising between 4% and 10% of an alkali metal alkylsulphate to reinforce the local availability of active principle and between 0.1% and 1% of a monohydrate sugar.

Prolonged release bioadhesive therapeutic systems

The present invention relates to a novel foam-forming composition suitable for rectal administration of locally-acting pharmaceutically active ingredients, and the product adapted to administer said foam-forming composition. Also, the present invention relates to a method for its preparation. According to the present invention a foam-forming composition is provided which exhibits a high expansion ratio and at the same time conferring optimal appearance of the formed foam to allow sufficient contact time of the active to the target site in the intestine in order to obtain optimal local effect. The composition according to the present inventions provides superior properties for the treatment of rectal diseases.

Foam-forming composition

An intraocular implant adapted to come in contact with the aqueous humor comprises a hydrophilic polymer having a predetermined water content for implantation in an eye, an effective quantity of a medicated product for treatment of the eye being dispersed in the mass of the hydrophilic polymer of the implant, the association of the hydrophilic polymer and the dispersed medicated product being adapted to release the product progressively into the aqueous humor.

Intraocular lens containing releasable medication

The present invention concerns a prolonged release bioadhesive mucosal therapeutic system containing at least one active principle, with an active principle dissolution test of more than 70% over 8 hours and to a method for its preparation. This bioadhesive therapeutic system comprises quantities of natural proteins representing 50% by weight of active principle and at least 20% by weight of said tablet, between 10% and 20% of a hydrophilic polymer, and compression excipients, and comprising between 4% and 10% of an alkali metal alkylsulphate to reinforce the local availability of active principle and between 0.1% and 1% of a monohydrate sugar.

The present invention concerns a prolonged release bioadhesive mucosal therapeutic system containing at least one active principle, with an active dissolution test of more than 70% over 8 hours and to a method for its preparation. The bioadhesive therapeutic system may be in tablet form and may contain quantities of natural proteins representing at least 50% by weight of active principle and at least 20% by weight of the tablet, between 10% and 20% of a hydrophilic polymer, and compression excipients, and may contain between 4% and 10% of an alkali metal alkylsulphate to reinforce the local availability of active principle and between 0.1% and 1% of a monohydrate sugar.

A device, enabling a therapeutic or cosmetic substance to be dispensed in the form of aerosol particles, is of the two-compartment type or has a pump body mounted on it, and a composition intended to be used in the device; the composition including an active substance and an inert vehicle, which is one or more polydiorganosiloxanes of sufficient volatility to ensure expulsion of the composition in the form of aerosol particles.

Device for dispensing a therapeutic or cosmetic substance onto the skin and a method of skin treatment

The present invention relates to an intra-ocular lens that is made from hydrophilic polymer. An effective amount of medicine is dispersed in the mass of the of the polymer and when implanted in the eye of a subject, the lens releases the medicine into the intra-ocular tissues so that the medicine is in the vicinity of the site where action is needed.

The invention concerns multilayer microspheres containing an acid substance, a basic substance, and a water-soluble isolating agent which, when it dissolves in water, after almost instant effervescence, brings about a homogeneous dispersion of active principal(s) which is present in the acid and basic substances. The invention also concerns a method for preparing such microspheres by rotational granulation on a fluid air bed associated with a system of tangential spraying of the wetting liquid.

Effervescent microspheres and method for making them

The present invention relates to a device enabling a therapeutic or cosmetic substance to be dispensed in the form of aerosol particles. The device according to the invention is of the two-compartment type or has a pump body mounted on it and has the characteristic feature that it contains a composition including an active substance and an inert vehicle which is one or more polydiorganosiloxanes of sufficient volatility to ensure expulsion of the composition in the form of aerosol particles. The invention also relates to the composition intended to be used in the device.

Growing community of inventors

Clermont-Ferrand, France

Jean-Marc Aiache