Rhone-poulenc Industries

Rhone-poulenc S.a.

Agence Nationale De Valorisation De La Recherche (anvar)

Jean Lunel

Jean Florent

Denise Mancy

Jean Preud'Homme

Andre Belloc

Jean-Claude Palla

Pierre Jolles

Daniele Migliore-Samour

Jacques Renaut

Bernard Vuillemin

Bernard Lombardi

The new water-soluble substance designated by the number 41,200 RP, is obtained from cells of Micrococcus sedogenes, M 78 strain (NRRL B-3505), and is particularly useful in human or veterinary therapy for increasing resistance to infections of various origins and for stimulating the natural defences of the organism.

Biologically active substance, its preparation and compositions

37,454 RP of the formula: ##STR1## and its non-toxic salts with metals and nitrogen-containing bases possess anti-coccidial activity.

Anti-coccidial substance and its preparation

A novel culture of the microorganism Streptomyces caligosus DS 14,486 and a novel proteolytic enzyme produced from cultivating the culture are disclosed. The enzyme has utility in the depilation of animal skins.

Microorganism and proteolytic enzyme derived therefrom

The glycopeptide 31,177 RP is prepared by cultivating under aerobic conditions in an aqueous nutrient medium Streptomyces calidus DS 26,320 (NRRL 8141), a hitherto unknown microorganism. 31,177 RP is of interest as an inhibitor of glyco-hydrolases, e.g. the amylases, the maltases or the saccharases, particularly those of the digestive tract.

Glycopeptide

The invention relates to novel water-soluble compounds, process for their preparation, methods of therapeutic treatment therewith and pharmaceutical compositions containing them. The compounds correspond to the formulae (III) and (IV) below or their mixtures in molar proportions of about 4/1, in which formulae X represents a RCO radical and Y represents a hydrogen atom or a RCO radical, or again in which Y represents a RCO radical and X represents a hydrogen atom or a RCO radical, R being an alkyl or alkenyl radical containing 11 to 19 carbon atoms in a straight or branched chain. ##STR1## The compounds are useful as immunological adjuvants.

Novel water-soluble compounds derived from extracts of streptomyces

The new antifungal agents 32232 RP and 35391 RP having the probable formulae: ##STR1## respectively, are prepared by cultivating the hitherto unknown microorganism Streptomyces incarnatus DS 26068 (NRRL 8089), under aerobic conditions in an aqueous nutrient medium to obtain 32232 RP which can be converted into the lactam 35391 RP.

.alpha.,.delta.-Diaminoacid and its lactam

The new antibiotic of the formula: ##STR1## wherein R represents the group--CONH.sub.2, designated 35665 RP, possesses growth-promoting properties when added to animal feed.

Polyheterocyclic-antibiotic

20,798 R.P., which has valuable anti-tumor properties, and acid addition salts thereof are prepared by the microbiological reduction of daunorubicin of the formula: ##SPC1## Or of an acid addition salt thereof, to convert the grouping --CO--CH.sub.3 to --CHOHCH.sub.3.

Process for the preparation of the antibiotic 20.798 R.P.

The antibiotic 20,798 R.P. of the formula: ##SPC1## Is of special interest because of its anti-tumor activity. The antibiotic is produced by culture of the microorganism Streptomyces coeruleorubidus (NRRL 3045).

Antibiotic 20,798 R.P.

The antibiotic 20,798 R.P. of the formula: ##SPC1## Is of special interest because of its anti-tumour activity, being particularly active against acute lymphoblastic and myeloblastic leucaemias. The antibiotic is produced by culture of the microorganism Streptomyces coeruleorubidus (NRRL 3045).

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Paris, France

Jean Lunel