Centre National De La Recherche Scientifique

Commissariat a L'energie Atomique

Aventis Pharma S.a.

Rhone-poulenc Rorer S.a.

Lesaffre Et Compagnie

Commissariat &#xc0; L'&#xc9;nergie Atomique Et Aux &#xc9;nergies Alternatives

Kyowa Hakko Bio Co., Ltd.

Université Paris—sud

Université Paris-Saclay

Cnrs

Jean-Luc Pernodet

Thomas Desfougeres

Patricia Lacroix

Michel M Guerineau

Roger Genet

Muriel Gondry

Sylvie Lautru

Karine Tuphile

Robert Thai

Claude Gerbaud

Juliette Hagege

Alain Raynal

Guennadi Sezonov

Maria Ball

Mylène Darricau

Asa Frostegard

Annick Friedmann

Guennady Sezonov

Camela Cappellano

Sophie Courtois

Pascal Simonet

Pascale Jeannin

Nathalie Oestreicher-Mermet-Bouvier

Fatma Karray

Anne Gondran

Emmanuelle Darbon-Rongere

François Francou

Marie-Hélène Blondelet-Rouault

Hélène Dominguez

Nathalie Oestreicher-Mermet- Bouvier

Marie-Helene Blondelet-Rouault

Helene Dominguez

Pascal Belin

Dominique Fourmy

Satoko Yoshizawa

Marie Ebeyer-masotta

The invention relates to anstrain derived from theZyl 926 strain having at least one additional copy of the FCS and ECH genes encoding feruloyl-CoA-synthetase and enoyl-CoA-hydratase/aldolase integrated at the integration site of the &#x3c6;C31 phage. The invention also relates to the method for producing such strains, the integration cassette of the FCS and ECH genes, the use of said strains in a method for producing vanillin, and a method for producing vanillin.

Bacterial strains for the production of vanillin

The invention concerns novel isolated natural or synthetic polynucleotides and polypeptides coded by said polynucleotides, involved in the synthesis of diketopiperazine derivatives, vectors comprising said polynucleotides, micro-organisms transformed with said polynucleotides, uses of said polynucleotides and said polypeptides, as well as methods for the synthesis of diketopiperazine derivatives, including cyclodipeptides and diketopiperazine derivatives 3- and 6-substituted by &#x3b1;,&#x3b2;-unsaturated amino acid side chains.

Polynucleotides and polypeptides coded by said polynucleotides involved in the synthesis of diketopiperazine derivatives

The invention concerns a method for preparing nucleic acids from an environment sample, more particularly a method for obtaining a library of nucleic acids from a sample. The invention also concerns nucleic acids of nucleic acid libraries obtained by said method their use in the synthesis of novel compounds, in particular novel compounds of therapeutic interest. The invent further concerns novel means used in the method for obtaining said nucleic acids, such as novel vectors and novel processes for preparing such vectors or recombinant host cells containing said nucleic acid. Finally, the invention concerns methods for detecting a nucleic acid of interest within a library of nucleic acids resulting from said method, and nucleic acids detected by said method and polypeptides encoded by said nucleic acids.

Method for obtaining nucleic acids from an environment sample, resulting nucleic acids and use in synthesis of novel compounds

The invention concerns novel isolated natural or synthetic polynucleotides and polypeptides coded by said polynucleotides, involved in the synthesis of diketopiperazine derivatives, vectors comprising said polynucleotides, micro-organisms transformed with said polynucleotides, uses of said polynucleotides and said polypeptides, as well as methods for the synthesis of diketopiperazine derivatives, including cyclodipeptides and diketopiperazine derivatives 3- and 6- substituted by &#x3b1;,&#x3b2;-unsaturated amino acid side chains.

Regulatory nucleic acid sequences and uses in actinomycetes

Growing community of inventors

Cachan, France

Jean-Luc Pernodet