Institut Pasteur

Centre National De La Recherche Scientifique

Institute Pasteur

Institut Pasteur Paris

Etablissement Declare D'utilite Publique Diti Institut Pasteur

Jean-Luc Guesdon

Stratis Avrameas

Christine Petit

Dominique Weil

Dominique Thierry

Sandrine Marlin-Duvernois

Philippe Kourilsky

Brigitte Gicquel

Anne Brisson-Noel

Françoise Denoyelle-Gryson

Francoise Denoyelle-Gryson

Veronique Stonnet

Brigitte Cami, Born Contamine

Sandrine Marlin

Jean-Claude Mazie

Agnes Ullmann

Francois Traincard

Therese Ternynck

Hiroshi Sakamoto

Avrameas Stratis

Tuyen Vo Quang

Veronique Vincent

Agn Es Ullmann

Agnes Ullman

Brigitte Cami Contamine

Brigitte Cami Nee Contamine

Fran&ccedil;oise Denoyelle-Gryson

A purified polynucleotide having a chain of nucleotides corresponding to a mutated sequence, which in a wild form encodes a polypeptide implicated in hereditary sensory defect wherein said mutated purified polynucleotide presents a mutation responsible for prelingual non-syndromic deafness selected from the group consisting of a specific deletion of at least one nucleotide.

Mutation within the connexin 26 gene responsible for prelingual non-syndromic deafness and method of detection

A purified polynucleotide having a chain of nucleotides corresponding to a mutated sequence, which in a wild form encodes a polypeptide implicated in hereditary sensory defect, wherein said mutated purified polynucleotide presents a mutation responsible for prelingual non-syndromic deafness selected from the group consisting of a specific deletion of at least one nucleotide.

A purified polynucleotide having a chain of nucleotides corresponding to a mutated sequence, which in wildtype form encodes a polypeptide implicated in hereditary sensory defect, wherein said mutated purified polynucleotide presents a mutation responsible for prelingual non-syndromic deafness selected from the group consisting of a specific deletion of at least one nucleotide.

A purified polynucleotide having a chain of nucleotides corresponding to a mutated sequence, which in wild-type form encodes a polypeptide implicated in hereditary sensory defect, wherein the mutated purified polynucleotide presents a mutation responsible for prelingual non-syndromic deafness selected from the group consisting of a specific deletion of at least one nucleotide.

A purified polynucleotide having a chain of nucleotides corresponding to a mutated sequence, which in a wild type form encodes a polypeptide implicated in hereditary sensory defect, wherein said mutated purified polynucleotide presents a mutation responsible for prelingual non-syndromic deafness selected from the group consisting of a specific deletion of at least one nucleotide.

Mutated polynucleotide corresponding to a mutation responsible for

Nucleotide sequence hybridizing specifically with a genomic nucleic

Method for detecting the possible presence of a DNA fragment, notably of a gene, in the midst of a complex sample of nucleic acids. It comprises the hybridization of the sought fragment with a RNA probe, this being, prior or subsequent to the hybridization reaction, modified by an enzyme. Application to seeking of particular genes or DNA fragments in the midst of a biological sample.

Method of detecting and characterizing a nucleic acid or reactant for

Method of detecting and characterizing a nucleic acid or a sequence of

Fragments of nucleic acids derived from an appropriate mycobacteria genome, particularly Mycobacterium tuberculosis, their applications in the diagnosis of mycobacteria infections, as well as plasmides containing said fragments. The nucleotidic sequence is comprised of a nucleotidic sequence repeated in the genome of a mycobacterium and specific of the bacillus of tuberculosis and is characterized by a strong hybridation with M. tuberculosis.

Mycobacterial nucleic acid hybridization probes and methods of use

The invention relates to a nucleic acid fragment derived from the Mycobacterium tuberculosis genome, characterized in that it contains one of the sequences I, II, III and IV, defined in the following manner:

Specific detection of the mycobacterium tuberculosis

Nucleotide sequences which hybridize specifically with a Campylobacter

Nucleotide sequences which hybridize specifically with bacterial strains

Growing community of inventors

Sevres, France

Jean-Luc Guesdon