Centre National De La Recherche Scientifique

Universitéde Strasbourg

Institut National De La Sante Et De La Recherche Medicale

Université Paris—sud

Centre National De La Recherche Scientifique-Cnrs

Université Louis Pasteur

Centre International De Recherche Aux Frontieres De La Chimie

Greenpharma

Université Louis Pasteur De Strasbourg

Greenpharma S.a.

Jean-Luc Galzi

Nelly Frossard

Marcel Francois Hibert

Franc Emile Pattus

Marcel Hibert

Sylviane Muller

Dominique Bonnet

Philippe Bernard

Christophe Guignabert

Dayana Abboud

Christelle Pillard

Quoc Tuan Do

Frédéric Simonin

Marcel Francois Louis Hibert

Christel Anne Franchet

Franc Emile Jean Pattus

Fabrice Yves Guillier

Philippe Alix

Marcel François Louis Hibert

A subject of the present invention is a compound having the general formula (I):  Another subject of the invention is the compound as defined above for use as a medicament, in particular for preventing and/or treating inflammation and inflammatory diseases, immune and auto-immune diseases, pain related diseases, genetic diseases and/or cancer.

Pyrimidinone derivatives and uses thereof to neutralize the biological activity of chemokines

The present invention relates to the cosmetic or pharmaceutical use for a composition comprising a salicylic or nicotinic acid derivative inhibiting chemokines, for preventing or treating chronic internal and/or external inflammatory conditions.

Dermocosmetic or pharmaceutical use of a composition comprising at least one inhibitor of some chemoattractant cytokines

The use of a collection of compounds of general formula (I), wherein: n is 0 or 1; p represents an integer between 1 and 6; r represents an integer between 1 and 12; Rand R'represent in particular a hydrogen atom; Rrepresents an amino acid side chain or an amino acid derivative; Rrepresents a group derived from a carboxylic acid, bearing a basic entity; Rrepresents in particular an alkyl group containing 1 to 10 carbon atoms; and A represents a hydrogen atom, a protecting group or a tracing group, in particular a fluorophor, a coloring agent or a quencher, for determining, through binding studies, ligands of receptors whose ligand is unknown or whose ligand useful for carrying out specific affinity binding assays is unknown.

Collection of traceable compounds and uses thereof

The invention relates to the use of a fluorescent protein chosen in particular from autofluorescent proteins,

Use of a fluorescent protein for detecting interaction between a target protein and its ligand

Growing community of inventors

Weitbruch, France

Jean-Luc Galzi