Imedex

Institut Merieux

Imedex Biomateriaux

Khorionyx

Societe Anonyme Dite: Institut Merieux

Other

Institut National De La Sante Et De La Recherche Medicale

Pasteur Merieux Serums Et Vaccins

Rhone-Poulenc Recherches

Societe Anonyme De Developpement Des Utilisations Du Collagene S.a.d.u.c.

Dibevial

Pasteur Merieux Serums and Vaccines

Pasteur Merieux Serum Et Vaccins

Jean-Louis Tayot

Michel A Tardy

Philippe Gravagna

Yves Bayon

Marie-Claude Mynard

Michel Therin

Alain Constancis

Jacques Marescaux

Fran&ccedil;ois R&eacute;gis Ory

Michel G Grandgeorge

Michel Lagarde

Jean-Luc B Veron

Jerome Tiollier

Michel Exertier

Henri Dumas

Ge/ Rard Soula

Jean Bernasconi

Ren&eacute; Labatut

Je/ Ro/ Tiollier

Veronique Chirouze

Jean-Marc Rouzioux

Frank Thies

Jean Lecerf

Martine Croset

Herve Volckmann

J Er Tiollier

Claude Rollin

Michel Marie Dubois

Jacques Coves

Adrien Dromard

A new preparation for regenerating tissues or healing wounds, which can be administered to a patient, which comprises serum and globin being insoluble at physiological pH, said preparation being obtained by adding said serum to said globin being insoluble at physiological pH.

Implantable preparations for regeneration of tissues and treatment of wounds, their method of preparation, and method of treatment of patients with said implantable preparations

The invention relates to a sterile preparation which can be implanted on or in organic tissues, comprising: a natural or modified globin material which is insoluble at physiological pH and/or a material obtainable from globin which has been modified to be soluble at physiological pH, the said materials being biocompatible and biodegradable in the organism; an agent selected from natural or synthetic polymeric adhesive agents, polymeric tissue enhancement or filling agents, more particularly an agent based on crosslinked hyaluronic acid or on polylactic acid, and a polymeric wound cicatrization agent, specifically oxidized cellulose; with the provisos that, if the preparation comprises the said material obtainable from globin modified so as to be at least partly soluble, the said polymeric adhesive agent, if present, is not hyaluronic acid or carboxymethylcellulose and the said polymeric enhancement or filling agent, if present, is an agent based on crosslinked hyaluronic acid, and that, if the preparation comprises oxidized cellulose, the latter is present in a proportion greater than that of the said globin material, which in that case is a natural or modified globin material which is insoluble at physiological pH; and the use of this preparation, more particularly for filling or cicatrization.

Preparation, for use, in particular, for tissue augmentation and healing

A bicomposite material based on collagen is prepared which has two closely bound layers and is biocompatible, non-toxic, hemostatic and biodegradable in less than a month, and can be used in surgery to achieve hemostasis and prevent post-surgical adhesion. To prepare the material, a solution of collagen or gelatin, which may contain glycerine and a hydrophilic additive such as polyethylene glycol or a polysaccharide, is poured onto an inert support to form a layer 30 &#x3bc;m to less than 100 &#x3bc;m thick. Then a polymeric porous fibrous layer is applied during gelling of the collagen or gelatin, and the resultant material is dried. The polymeric porous fibrous layer may be made of collagen or a polysaccharide, and have a density of not more than 75 mg/cm, a pore size from 30 &#x3bc;m to 300 &#x3bc;m and a thickness of 0.2 cm to 1.5 cm.

Method for preparing two-layer bicomposite collagen material for preventing post-operative adhesions

A preparation is provided which can be injected or implanted into the human or animal body, and which comprises, as main component, globin that is insoluble at physiological pH, biocompatible and sterile.

Injectable implant of insoluble globin

A biocompatible fluid adhesive protein foam, which is bioresorbable and nontoxic, for surgical and/or therapeutic use, in particular for protecting/cicatrizing tissue wounds and for attaching biological tissues to each other or to an implanted biomaterial. The biocompatible fluid adhesive protein foam includes a biocompatible fluid adhesive protein matrix, which is bioresorbable and nontoxic, containing a biocompatible and nontoxic gas or mixture of gases. Further, a process and a kit for preparing such a foam are provided.

Adhesive protein foam for surgical and/or therapeutic uses

The invention concerns a method for preparing a non-toxic, sterile, biocompatible, crosslinked collagen material with controlled in vivo biodegradation speed. It consists in subjecting a collagen constituent, either to beta radiation, or to gamma radiation. The collagen material obtained is biodegradable in a few days depending on the type of irradiation used.

Method for preparing a collagen material with controlled in vivo degradation

A device for the formation and delivery of a mixture, notably a surgical adhesive, consisting of a receptacle adapted for easy handling by the surgeon, and including the means of receiving two syringe barrels containing the constituents of the mixture, the means of simultaneously expelling the contents, the means of maintaining the contents of syringe containing the first constituent, at a predetermined temperature setting which is higher than body temperature, and a mixer simultaneously receiving the contents of the two syringes, and the mixer also being used for cooling.

Device for forming and delivering a mixture

The composite prosthesis comprises a prosthetic fabric having a three-dimensional structure separating two surfaces, one of which is open to post-surgical cell colonization. The composite prosthesis further comprises at least one film of a collagenous material linked to the other surface of the prosthetic fabric. The composite prosthesis may be used to prevent post-surgical adhesion.

Composite prosthesis for preventing post-surgical adhesions and method for obtaining same

The present invention relates to a biocompatible collagenous material which is non-toxic and biodegradable in less than one month, preferably in less than one week. This material comprises collagen and at least one hydrophilic macromolecular additive which is chemically non-reactive towards the collagen, with the collagen having at least partially lost its helical structure and being crosslinked. The invention also relates to a process for obtaining such a material. The collagenous material according to the invention is used, in particular, for preventing post-operative adhesions.

Collagenic material useful in particular for preventing post-operative adhesions

The present invention is drawn to method for removing unconventional transmissible agents (UCTA) from aqueous protein solution. This method involves treating the aqueous protein solution with simultaneous electrostatic adsorption and hydrophobic chromatography. The method of the present invention is particularly suitable for treating calf serum or an albumin solution.

Method for removing unconventional transmissible agents from a protein solution

Adhesive composition with macromolecular polyaldehyde base and method

Polyunsaturated fatty acid based drugs

The invention relates to a biocompatible, bioresorbable and non-toxic adhesive composition for surgical use, for the bonding, in particular, of biological tissues to one another or in an implanted biomaterial, characterized in that it comprises a reactive acidic solution of non-crosslinked and potentially crosslinkable collagen or gelatin modified by oxidative cleavage, at a concentration which is preferably between approximately 5 and 30 by weight. It also relates to reactive acidic solutions and powders based on non-crosslinked collagen or gelatin modified by oxidative cleavage which are used as intermediate products in the preparation of the above-mentioned composition, and to the process for their preparation. It also relates to adhesive kits which comprise, on the one hand, the above-mentioned reactive acidic solution and, on the other hand, a neutralizing solution and which are intended for extemporaneous mixing. Finally it relates to a method of application of the adhesive, composition according to the invention. The invention is particularly useful in the areas of adhesion, haemostasis, leaktightness with respect to liquids or gases, cicatrization, filling, avoiding adhesion in surgery, embolization, as a local system for release of medicamentary active principles, etc.

Biocompatible bioresorbable and non-toxic adhesive composition for

The invention relates to an adhesive, biocompatible, biodegradable and non-toxic composition for surgical use, in particular for binding tissues, which composition is of the following general formula: ##STR1## in which: R is a hydrocarbon chain containing from 1 to 50 carbon atoms,

Adhesive compositions for surgical use

Human or animal placenta is subjected to moderate enzymatic digestion, in particular with pepsin at an acid pH, then, after separation of the residual tissue the impurities are separated at a moderately acid pH, the collagen is precipitated at a neutral pH, redissolved and the residual impurities precipitated at an acid pH. The collagen obtained can be brought back to a neutral pH and dried in the form of fibres. Completely transparent, physiological and hemocompatible gels and solutions can be prepared. Applications for the fabrication of contact lenses and implants.

New preparation of placenta collagen, their extraction method and their

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La Tour de Salvagny, France

Jean-Louis Tayot