Universitât Bern

Proteus Gmbh

Universite De Berne

Proteus S.a.

Université De Genve

Universitè De Genève

Jean-Louis Reymond

Jurg Gertsch

Simon Nicolussi

Denis Wahler

Olivier Jordan

Hong-Khanh Nguyen

Tamis Darbre

Viorica Patrulea

Gerrit Borchard

Michaela Stach

Bee Ha Gan

Frabrizzio Badalassi

Jürg Gertsch

Fabrizzio Badalassi

The invention relates to a bio-conjugate comprising a chitosan derivative coupled to an antimicrobial peptide (AMP) for use in the treatment or prevention of a microbial infection, for example in wound healing. The invention also provides a nanoparticle formulation or a gel/hydrogel formulation or a lyophilized foam formulation comprising the bio-conjugate of the invention.

Antimicrobial tailored chitosan

The invention relates to a compound comprising the following general formula (1): and said compound for use as a medicament, in particular for use in the treatment psychiatric or neurological disorders and inflammation, in particular neuroinflammation: (formula 1) wherein each of R1, R2 and R3 are selected independently from each other from alkyl, alkoxy, alkenyl, alkynyl, cycloalkyl, aryl, heterocycle, or heteroaryl.

Substituted 2-imino-1,3-thiazolidin-4-ones as N-arachidonoylethanolamine cellular uptake inhibitors

The invention relates to a peptide dendrimer described by a general formula X&#x2014;(B&#x2014;[Y]-D)-B&#x2014;Z, wherein X is (D)4 or (D)-(B&#x2014;[Y]-D)or a higher analog, Y is a linkage moiety, Z is a central moiety; each B denotes a diaminoalkylcarboxylic acid moiety; each D is a hydrophobic or cationic amino acid, or a di- or tripeptide composed of hydrophobic and cationic amino acids, for use as a pharmaceutical.

Antimicrobial peptide dendrimers

The invention relates to a compound comprising the following general formula (1) for use in the treatment of psychiatric or neurological disorders and inflammation, in particular neuroinflammation: (1) wherein each of R1, R2 and R3 are selected independently from each other from alkyl, alkoxy, alkenyl, alkynyl, cycloalkyl, aryl, heterocycle or heteroaryl.

Thiazolidinones as cellular anandamide uptake inhibitors and their use in the treatment of psychiatric or neurological disorders and inflammation, in particular neuroinflammation

The invention relates to a compound comprising the following general formula (1): and said compound for use as a medicament, in particular for use in the treatment psychiatric or neurological disorders and inflammation, in particular neuroinflammation: (formula 1) wherein each of R, Rand Rare selected independently from each other from alkyl, alkoxy, alkenyl, alkynyl, cycloalkyl, aryl, heterocycle, or heteroaryl.

This invention has as its object a method for releasing a product by subjecting a compound of Formula (II'): R&#x2032;R&#x2032;(HX)C-C(YH)R&#x2032;R&#x2032;to a chemical oxidation that cleaves the bond C-Cto obtain the product. In the compound of Formula (II&#x2032;): R&#x2032;to R&#x2032;, which are identical or different, correspond to a hydrogen atom, a substituted or unsubstituted alkyl group, or a substituted or unsubstituted functional group; X and Y, which are identical or different, are an oxygen atom, a sulfur atom, or an amine of Formula &#x2014;NRR, wherein Ris a hydrogen atom, an alkyl group, or a substituted or unsubstituted aryl group, and Ris not a hydrogen atom. The invention also has as its object a method for releasing a product that comprises, before the chemical oxidation stage, a first step for preparing the compound of Formula (II&#x2032;). The released product can be a volatile molecule or an active substance or else a specific product. The invention also relates to a method for detecting the released product as well as its applications, in particular for detecting catalytic or enzymatic activities.

Method for releasing a product comprising chemical oxidation, method for detecting said product and uses thereof

This invention has as its object a process for generating the idiosyncratic catalytic imprint of a sample, characterized in that it comprises the following stages: the sample that is likely to have the catalytic activity is brought into contact with a group of substrates; the signals that are generated after said contact are captured in some way. Advantageously, after the signals are captured, a processing of the latter that consists of assigning to each signal a digital value constituting a component of a graphic display, for example a color display, of the idiosyncratic imprint is carried out.

Process for generating the idiosyncratic catalytic imprint of a sample, the processing of said imprint and the systems for implementation thereof

This invention has as its object a method for detecting catalytic activity of a sample, characterized in that it comprises: the incubation of a substrate (S) with the sample that may have the catalytic activity that it is desired to detect, the addition of a reagent (X) that can react either with a chemical group of unconsumed substrate (S) or with a chemical group of product (P) that is formed after an incubation period with the sample, the addition of a developer (R) that can react with reagent (X), and the detection of the transformation of developer (R).

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Bulle, Switzerland

Jean-Louis Reymond