Institut National De La Sante Et De La Recherche Medicale

Sorin Crm Sas

Université Joseph Fourier

Université De Rennes 1

Université Joseph Fourier - Grenoble 1

Universite Rennes 1

Université Grenoble Alpes

Inserm (institut National De La Sante Et De La Recherche Medicale)

Jean-Louis Pépin

Alfredo Hernandez

Amel Amblard

Laurence Graindorge

Delphine Feuerstein

Marcel Limousin

Christine Henry

Laure Duchemin Laporte

Maurice Dematteis

Patrick Levy

A device for treating sleep apnea by discriminating between successive sleep stages of a patient includes a generator configured to produce stimulation pulses, a stimulator that receives the stimulation pulses produced by the generator and delivers stimulation to the patient, a sensor configured to measure a biological parameter of the patient, and a controller. The controller is configured to determine a state of the patient based on the biological parameter, perform a sleep analysis based on the state of the patient, activate the generator to trigger production of the stimulation pulses, determine a variation of the biological parameter subsequent to the production of the stimulation pulses, determine a response of the patient to the stimulation pulses according to the variation of the biological parameter, and determine a sleep stage of the patient based on the response.

Device for discrimination of stages of a patient's sleep

A system includes a processor configured to generate stimulation control signals in response to a detection of a respiratory disorder. The system further includes at least one kinesthetic effector with a vibrating electromechanical transducer applied to a site on a patient's skin for delivering a kinesthetic stimulation energy determined by the control signals. The processor is further configured to determine the effectiveness of a stimulation by detecting a cessation of the respiratory disorder. The processor is further configured to extend the stimulation control signals for a determined duration following the cessation of the respiratory disorder.

System for respiratory disorder therapy with stabilization control of stimulation

A device includes a processor configured to detect a respiratory disorder episode and generate kinesthetic stimulation control signals in response to the detection of a respiratory disorder episode. The device further includes at least one kinesthetic effector adapted to be applied to a patient's outer skin site and includes a vibrating electromechanical transducer capable of receiving stimulation control signals and outputting a kinesthetic stimulation energy determined by the stimulation control signals. The processor is further configured to determine the effectiveness of stimulation by detecting a cessation of the respiratory disorder episode. The processor is further configured to determine a stimulation energy by selecting an initial energy value and varying the energy value as a function of the effectiveness of previous stimulation.

Device for optimization of sleep apnea syndrome therapy by kinesthetic stimulation

A system includes a processor configured to generate stimulation control signals in response to a detection of a respiratory disorder. The system further includes at least one kinesthetic effector with a vibrating electromechanical transducer applied to a site on a patient's skin for delivering a kinesthetic stimulation energy determined by the control signals. The processor is further configured to determine the effectiveness of a stimulation by detecting a disappearance of the respiratory disorder. The processor is further configured to determine a therapy by selecting a stimulation strategy among several stimulation strategies according to a type of expected or detected disorder.

System for respiratory disorder therapy with selection of stimulation strategies

A device for treating sleep apnea in a patient through stimulation. The device includes a generator configured to produce stimulation pulses, a stimulator that receives the stimulation pulses produced by the generator and delivers stimulation to the patient, and a controller. The controller is configured to determine a sleep state of the patient, adaptively control the generator based on the sleep state where the sleep state includes a plurality of sleep stages, and modulate a stimulation energy of the stimulation pulses produced by the generator based on the sleep stage of the patient.

Device for the treatment of sleep apnea syndrome in a patient by kinesthetic stimulation

To assess the sensitivity of a subject's pharynx, an open mouthpiece () fitted with a thin guide tube (), having an articulated end (), is inserted into the subject's mouth. A pipe () is inserted into the guide tube, under visual observation through the mouthpiece, until it touches the subject's palate. The position on a measurement scale () provided on the pipe facing a second end of the guide tube is noted, and the pipe is withdrawn over a preset distance, for example 1 cm, and fixed in this position onto the guide tube. A variable gas flow is injected into the pipe and reaches the pharyngeal mucous situated facing the pipe. The sensitivity of the subject's pharynx, measured by the threshold of sense perception, is determined by the lowest flow value perceived by the subject.

Mouthpiece intended for a device used to assess the sensitivity of the pharynx and a device comprising same

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Grenoble, France

Jean-Louis Pépin