Centre National De La Recherche Scientifique

Ecole Polytechnique

Jean-Louis Leroy

Denis Pompon

Aude Laisne

Kalle Gehring

Maurice Gueron

The present invention pertains to a supramolecular structure based on i-motif tetramers of C&#x2014;X&#x2014;Coligonucleotides, wherein m and n are integers comprised between 2 and 9, and X is a linker such as A, T, G, a modified deoxynucleotide or a diol spacer. These supramolecular structures can be dissociated, when necessary, by a mere pH change. The present invention also relates to methods for obtaining such a supramolecular structure.

Multidimensional supramolecular structures essentially made of assembled i-motif tetramers

An `i-motif` nucleic acid, DNA and/or RNA, complex characterized by the presence of at least four cytosine-rich stretches or stretches rich in cytosine derivatives, including two parallel-stranded duplexes in which the cytosines or derivatives thereof form base pairs, said two duplexes being associated anti-parallel to one another, and said pairs of cytosine or derivatives thereof of one duplex being intercalated with those of the other duplex.

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Antony, France

Jean-Louis Leroy