Laboratoires Andre Guerbet

Guerbet S.a.

Jean Lautrou

Guy Tilly

Michel Jean Hardouin

Bruno Bonnemain

Michel Jean-Charles Hardouin

Dominique Meyer

Ioana Dimo

M Jean-Charles Hardouin

Jean C Hardouin

Lysine salt of the gadolinium-dota complex and its diagnostic

X-ray contrast media, for which the human body has a greater tolerance than that of contrast media comprising solely iodobenzene compounds, and an opacity of the same order of magnitude as the latter contrast media, comprise mixtures of benzene compounds nuclearly substituted with a plurality of iodine atoms and of benzene compounds nuclearly substituted with a plurality of bromine atoms, the bromobenzene compounds having the mole ratio from 1/2 to 2/1 to the iodobenzene compounds in the mixture.

Process for increasing the tolerance of X-ray contrast media, and

This invention relates to compounds of the formula (I): ##STR1## in which: n is an integer from 1 to 5 inclusive,

Ionic polyiodo benzene derivatives useful as X-ray contrast media

This invention relates to compounds of the formula: ##STR1## in which: R.sub.1 represents a hydrogen atom or a C.sub.1-4 alkyl radical or a C.sub.1-4 hydroxyalkyl radical,

Polyiods benzene derivatives and X-ray contrast media containing the same

The present invention provides new iodobenzene derivatives which have at least two benzene nuclei and one carboxylic group. These derivatives possess a low toxicity and may be used as X-ray contrast media.

Iodobenzene derivatives and X-ray contrast media containing the same

The present invention provides new iodo benzene derivatives which have at least two benzene nuclei and one carboxylic group. These derivatives possess a low toxicity and may be used as X-ray contrast media.

X-Ray contrast media

X-ray contrast media

This invention relates to compounds having the following general formula: ##STR1## in which n is an integer from 0 to 4; R.sub.1 and R.sub.2 represent independently from each other a radical of the formula --CONHR.sub.5 in which R.sub.5 is an alkyl radical having 1-4 carbon atoms or a hydroxyalkyl radical having 1-4 carbon atoms or a radical of the formula ##STR2## in which R.sub.6 and R.sub.7 are alkyl radicals having 1-4 carbon atoms; and R.sub.3 and R.sub.4, independently from each other, represent a hydrogen atom or an alkyl radical having 1-4 carbon atoms. Said compounds are useful as X-ray contrast media, particularly for myelography.

This invention relates to compounds of the formula: ##STR1## in which: R.sub.1 represents a hydrogen atom or a radical of the formula ##STR2## in which R.sub.4 and R.sub.5 represent, independently of each other, a hydrogen atom or a lower alkyl radical,

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Aulnay-sous-Bois, France

Jean Lautrou