Wisconsin Alumni Research Foundation

Dow Agrosciences LLC

Phyton Holdings, LLC

Jean L Roberts

Donald J Merlo

Lining Guo

James K Petell

Kitisri Sukhapinda

James A Strickland

Timothy Denver Hey

Ann Owens Merlo

Barry W Schafer

Rod Aaron Herman

Thomas A Rocheleau

David J Bowen

Richard H Ffrench-Constant

Jerald Coleman Ensign

Gregory L Orr

Todd A Ciche

Raymond Fatig

Sue Schoonover

Michael B Blackburn

Andrew C Hiatt

Joseph F Petolino

Dayakar Reddy Pareddy

Mich B Hein

W H Kerr Anderson

Beth C Rubin-Wilson

Kristen Briggs

Todd Glancy

Anton S Karnoup

Doug Taylor

This invention provides for the plant production of immunoglobulins, wherein at least a portion of the glycans attached to the immunoglobulins lack fucose. The invention also provides the constructs; plasmids; vectors; transformed plant cells, transformed plant calli; transformed plant tissues (e.g., leaves, seeds, tubers, etc.); transformed whole plants used to produce such immunoglobulins; methods of producing the immunoglobulins; the immunoglobulins produced by the disclosed methods; and the use of such immunoglobulins.

Plant production of immunoglobulins with reduced fucosylation

Proteins from the genusare toxic to insects upon exposure.(formerly) have been found in mammalian clinical samples and as a bacterial symbiont of entomopathogenic nematodes of genus. These protein toxins can be applied to, or genetically engineered into, insect larvae food and plants for insect control.

Nucleic acid encoding an insecticidal protein toxin from photorhabdus

Novel polynucleotide sequences that encode insect toxins TcdA and TcbA have base compositions that differ substantially from the native genes, making them more similar to plant genes. The new sequences are suitable for use for high expression in both monocots and dicots. Transgenic plants with a genome comprising the nucleic acid of SEQ ID NO:4 are insect resistant.

Transgenic plants expressing photorhabdus toxin

Novel polynucleotide sequences that encode insect toxins TcdA and TcbA have base compositions that differ substantially from the native genes, making them more similar to plant genes. The new sequences are suitable for use for high expression in both monocots and dicots. Transgenic plants with a genome comprising a nucleic acid of SEQ ID NO: 3 or SEQ ID NO:4 are insect resistant.

Proteins from the genus Photorhabdus are toxic to insects upon exposure. (formerly ) have been found in mammalian clinical samples and as a bacterial symbiont of entomopathogenic nematodes of genus Heterorhabditis. These protein toxins can be applied to, or genetically engineered into, insect larvae food and plants for insect control.

Insecticidal protein toxins from Photorhabdus

Growing community of inventors

Arcadia, IN, United States of America

Jean L Roberts