Sanofi-aventis

Sanofi-synthelabo

Sanofi

Jean Jeunesse

Christian Hoornaert

Alistair Lochead

Samir Jegham

Ahmed Abouabdellah

Luc Even

Alain Nedelec

Frederic Puech

Philippe Burnier

Fr&eacute;d&eacute;ric Galli

Antonio Almario Garcia

Frank Marguet

Regine Bartsch

Dorothee Cheuret

Régine Bartsch

Dorothée Cheuret

The disclosure relates to hexafluoroisopropyl carbamate derivatives of general formula (I): in which:

Hexafluoroisopropyl carbamate derivatives, their preparation and their therapeutic application

Therapeutic uses of a compound corresponding to the general formula (I): in which A=N or CR; R=H, F, OH, CN, CF, C-alkyl, C-alkoxy; n=2 or 3 and m=2 when A=N; n=1, 2 or 3 and m=1 or 2 when A=CR; B=covalent bond or C-alkylene; R=optionally substituted heteroaryl; R=CHRCONHR; R=H or C-alkyl; R=H, C-alkyl, C-cycloalkyl, C-cycloalkyl-C-C-alkylene;in the form of a base, an acid-addition salt, a hydrate or a solvate.

Therapeutic uses of derivatives of piperidinyl- and piperazinyl-alkyl carbamates

The present invention comprises peridinylalkylcarbamate derivatives, methods for their preparation and the therapeutic use thereof as fatty acid amido hydrolase (FAAH) enzyme inhibitors. These derivatives exert various pharmacological activities by interacting, inter alia, with cannabinoid and vanilloid receptors. By inhibiting the metabolic activity of the FAAH enzyme, compounds often responsible for the onset of a large variety of diseases and other pathological conditions are not generated and the incidence of the disease is greatly reduced.

Piperidinylalkylcarbamate derivatives, methods for their preparation and the therapeutic use thereof as fatty acid amido hydrolase enzyme inhibitors

Compound corresponding to the general formula (I): in which A=N or CR; R=H, F, OH, CN, CF, C-alkyl, C-alkoxy; n=2 or 3 and m=2 when A=N; n=1, 2 or 3 and m=1 or 2 when A=CR; B=covalent bond or C-alkylene; R=optionally substituted heteroaryl; R=CHRCONHR; R=H or C-alkyl; R=H, C-alkyl, C-cycloalkyl, C-cycloalkyl-C&#x2013;C-alkylene; in the form of a base, an acid-addition salt, a hydrate or a solvate. Therapeutic uses thereof.

Derivatives of piperidinyl-and piperazinyl-alkyl carbamates, preparation methods thereof and application of same in therapeutics

The invention relates to 2,5-diazabicyclo&lsqb;2.2.1&rsqb;heptane derivatives, to pharmaceutical compositions containing them, and to methods for the treatment or prevention of disorders associated with a dysfunction of the nicotinic receptors utilizing them.

2,5,-diazabicyclo&lsqb;2.2.1&rsqb;heptane derivatives, their preparation and therapeutic uses

The invention relates to 1,4-diazabicyclo&lsqb;3.2.2&rsqb;nonane derivatives, to pharmaceutical compositions containing them, and to methods for the treatment or prevention of disorders associated with a dysfunction of the nicotinic receptors utilizing them.

1,4-diazabicylo&lsqb;3,2,2&rsqb;nonane derivatives, their preparation and their therapeutic application

Compounds corresponding to the general formula (I)

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Paris, France

Jean Jeunesse