Pierre Fabre Dermo-Cosmetique

Université Paul Sabatier (Toulouse III)

Jean-Jacques Perie

Daniel Redoules

Roger Tarroux

Pascal Bordat

Didier Fournier

The invention concerns a bioprecursor of formula (I), wherein Aand Arepresent independently of each other a radical derived from a molecule capable of being used in dermatology or in cosmetology; X and Y represent independently of each other a hydrogen atom, a hydroxy group or a C&#x2013;Calkyl group; and n represents an integer between 0 and 10 

Bioprecursors for percutaneous application

The present invention relates to a ternary glucosyl complex which is a bioprecursor of at least one retinoic active ingredient for percutaneous application, having formula (I), wherein E represents a linear hydrocarbon spacer group that is branched or cyclized and has an aliphatic or aromatic content capable of containing one or several heteroatoms of oxygen and carrying one or several carbonyl groups; A represents a radical of a molecule of said retinoic active ingredient linked to the spacer group by a carboxylate function and n&equals;1 or 2.

Bioprecursors of a retinoic derivative and pharmaceutical and/or cosmetic compositions

The invention concerns a composition capable of being hydrolyzed by a cutaneous enzyme, glucocerebrosidase. The active precursor is advantageously a gluco-conjugate derived from phenol whereof the two &agr; carbons are free. The invention also concerns the use of such compositions against light-induced skin ageing or for making a medicine for treating certain skin diseases. The invention further concerns novel glucosylated compounds.

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Castanet, France

Jean-Jacques Perie