Zlb Bioplasma Ag

Rotkreuzstiftung Zentrallaboratorium Blutspendedienst

Rotkreuzstiftung Zentrallaboratorium Blutspendedienst Skr

Jean-Jacques Morgenthaler

Adames Omar

Markus Rentsch

Jacques-Andre Maring

For separating non-conventional transmissible agents (NCTAs), i.e. causative agent(s), of transmissible spongiform encephalopathies (TSEs) from a solution of a protein susceptible to contamination with NCTAs, particularly from blood products, at least one adsorbent is suspended, for a time of at least 10 minutes. The absorbent is selected from kieselguhr, diatomaceous earth, silicic acid, clay minerals, metal hydroxide, metal oxihydrate, cellulose, perlite, bentonite, and water-insoluble synthetic polymers. The obtained suspension is agitated, and subsequently the adsorbent is separated from the protein solution.

Method for the removal of causative agent(s) of transmissible spongiform encephalopathies from protein solutions

In order to separate viruses from protein solutions, particles of a solid phase are suspended in said protein solution. The solid phase is an adsorbent chosen from the group kieselguhr, silicic acid, clay minerals, metal hydroxide or oxihydrate, cellulose, perlite, and water insoluble synthetic polymers. Subsequently the solid phase together with the viruses that have adsorbed to it is separated from the fluid phase. The protein solution is brought into contact at least once with the solid phase for at least 10 minutes during which time a suspension is formed; subsequently the solid phase is separated from the liquid phase.

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Boll, Switzerland

Jean-Jacques Morgenthaler