Compagnie Generale Des Etablissements Michelin

Pierre Fabre Medicament

Armines

Association Pour La Recherche Et Le Developpement Des Methodes Et Processus Industriels

Jean-Jacques Letourneau

Jacques Fages

Martial Sauceau

Jose Merino Lopez

Frédéric Pialot

Bernard Freiss

Nathalie Coste

Hubert Lochard

Christophe Joussot-Dubien

Florence Marciacq

A process for manufacturing rubber crumb comprises the following steps: (a) suspending rubber granules having a given size in an autoclave () containing a supercritical fluid; (b) agitating the mixture for a predetermined time at constant pressure and constant temperature; (c) carrying out an isenthalpic expansion of the mixture from step (b) by spraying it through a nozzle ().

Method for producing rubber crumb, and rubber crumb

The invention concerns a method for preparing compounds for interaction of an active substance hardly soluble in an aqueous medium with a porous support. The invention is characterized in that it comprises the following steps: (a) mixing the active substance generated by supercritical fluid and the specific amount of porous support; (b) carrying out a molecular diffusion step by contacting in static mode a supercritical fluid with the mixture obtained at step (a) for the time required to improve the dissolution in the aqueous medium of the mixture obtained at step (a); (c) washing the interactive compound obtained at step (b) with a supercritical fluid flow; (d) recuperating the particles of the interactive compound thus formed. The invention also concerns a compound obtainable by said method.

Method for preparing a compound of interaction of active substances with a porous support using supercritical fluid

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Gragnague, France

Jean-Jacques Letourneau