Lipha, Lyonnaise Industrielle Pharmaceutique

Merck Patent Gesellschaft MIT Beschrankter Haftung

Merck Patent Gmbh

Merck Patent Gesellschaft

Lipha

Jean-Jacques Berthelon

Philippe Briet

Jean-Claude Depin

Jean-Jacques Zeiller

Francois Collonges

Eugene Boschetti

Francis Contard

Michel Brunet

Gerd Bartoszyk

Hartmut Greiner

Henning Bottcher

Didier Roche

Daniel Guerrier

Valérie Guyard-Dangremont

Philippe Durbin

Ralf M Devant

Marc Noblet

Janine Chabert

Eric Rasp&eacute;

Fréderic Ausseil

Hervé Dupont

Roche Didier

The present invention relates to a compound of the formula I: (Formula I) in which: A, B, R, Z, n and Rare as defined in claim. These compounds are useful in the treatment of dyslipidaemia, atherosclerosis and diabetes. 

Butyric acid derivatives

The invention concerns a benzodiazepin derivative of formula (I) and their use for treating dyslipidemia, atherosclerosis, diabetes and its complications.

Dihydrobenzodiazepins and their use for treating dyslipidemia

The present invention relates to cyclic compounds which are of the class of compounds of formula I wherein X and Y represent an oxygen atom and to processes for preparing such compounds. The compounds are useful in the treatment of dyslipidemia, atherosclerosis, and diabetes.

Cyclic compounds useful in the treatment of dyslipidaemia, atherosclerosis and diabetes, pharamaceutical compositions and preparation process

Aminoalkanesulphonic acid derivatives, their preparation and their use as medicaments

Amino(thio)ether derivatives of formula I ##STR1## wherein R.sup.0, R.sup.1, R.sup.2, R.sup.3, R.sup.6, R.sup.7, R.sup.8, R.sup.9, X and Z are as defined herein, and their salts, are active on the central nervous system.

Pyridyl chroman

Substituted six-membered benzo-fused heterocycles of the formula (I) ##STR1## in which: X=0, NH, S.fwdarw.(O).sub.n (n=0 or 2);

Pharmaceutically useful flavonoic compounds containing at least one

The invention concerns [oxo-4-4H-[1]-benzopyran-8-yl]-alcanoic acids and their derivatives, their manufacture, represented by the formula. ##STR1## where AR is hydrogen, a phenyl radical which may or may not be substituted thenyl, furyl, naphthyl, a lower alkyl, cycloalkyl, aralkyl radical; B is a linear or branched lower alkyl radical, either saturated or ethylinically unsaturated; R.sub.1 is hydrogen or a phenyl radical; X is hydrogen or a lower alkyl or alkoxy radical and n=1, as well as salts, esters, aminoesters and amides. Compounds and their derivatives may be used as medicines, in particular in the control of tumors.

[Oxo-4-4H-[1]-benzopyran-8-yl]alcanoic acids, salts and derivatives,

The invention concerns: (oxo-4-4H-(1)-benzopyran-8-yl) alkanoic acids and their derivatives, their manufacture, represented by the formula: ##STR1## where Ar is hydrogen, a phenyl radical which may or may not be substituted, thenyl, furyl, naphthyl, a lower alkyl, cycloalkyl, aralkyl radical; B is a linear or branched lower alkyl radical, either saturated or ethylinically unsaturated; R.sub.1 is hydrogen or a phenyl radical; X is hydrogen or a lower alkyl or alkoxy radical and n=1, as well as salts, esters, aminoesters and amides. Compounds and their derivatives may be used as medicines, in particular in the control of tumors.

(Oxo-4-4H-(1)-benzopyran-8-yl) alkanoic acids, salts and derivatives,

The invention relates to hydroxy-4-2H-1-benzothiopyran-2-ones, represented by the following formula: ##STR1## in which, when R.sub.1 is hydrogen, R and AR' can form a tetrahydronaphtyl cycle; R and R.sub.1 can form a carbonyl group; R is a hydroxyl group when R.sub.1 is hydrogen; AR is a biphenyl or phenoxyphenyl group, which is substituted or non-substituted by a halogen, and AR' is a substituted or non-substituted phenyl group which may form with R a tetrahydronaphtyl cycle or a thienyl group. These compounds have interesting properties and may be used in particular as rodenticides.

Rodenticidal 4-hydroxy-2H-1-benzothiopyran-2-one derivatives,

Novel 3-substituted-4-aminoalkoxy-5,6-condensed ring-2-pyranones are disclosed as having utility as pharmacologically active compounds, in particular vasodilatory, hypotensive, anti-ischemic and anti-tussive activity. The compounds may be 3-phenyl-4-morpholinoalkoxy-coumarins. Administration may be by the oral or parenteral route. Intermediates useful in the production of these compounds are also disclosed.

3-Substituted-4-aminoalkoxy-5,6-condensed ring-2-pyranones

Substituted hexahydro benzopyrano [3,2-c] pyridines, useful as antidepressants, have the formula ##STR1## where R is hydrogen or a saturated or unsaturated, linear or branched, lower alkyl, or an aralkyl, acyl, dialkylaminoalkyl, carbonylalkyl, alkoxycarbonyl, haloalkoxycarbonyl or aryl radical; R.sub.1 is hydrogen, halogen, or lower alkoxy; R.sub.2 is hydrogen or halogen; R.sub.3 is hydrogen, halogen, lower alkyl, alkoxy nitro or amino, or forms naphthalene with R.sub.4 and the benzene ring; R.sub.4 is hydrogen, a halogen, or forms naphthalene with R.sub.3 and the benzene ring; R.sub.5 is hydrogen, lower alkyl, or aralkyl.

Antidepressant substituted hexahydro benzopyrano [3,2-c] pyridines

Propionic acids and their functional derivatives having anti-inflammatory and analgesic properties correspond to the formula ##STR1## in which X is selected from phenyl, halophenyl, polyhalophenyl, lower alkylphenyl, trihalomethylphenyl, aryloxyphenyl, furyl and thienyl and R is selected from hydrogen, lower alkyl, lower omega-hydroxyalkyl, morpholinoethyl and lower dialkylaminoalkyl.

6',2-(2'Arylchromonyl) propionic acids, and analgesic and

6',2-(2'-Arylchromonyl) propionic acids, and analgesic and

The compound .alpha.-[6-(2-phenyl)-chromonyl]-acetic acid has choleretic and anti-inflammatory activity and is of use in the treatment of hepatic conditions.

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Lyons, France

Jean-Jacques Berthelon