Ciba-geigy Corporation

Ciba-geiby Corporation

Jean J Gallay

Manfred Kuhne

Georg Pissiotas

Elmar Sturm

Urs Burckhardt

Dieter Reinehr

Ernst Beriger

Haukur Kristinsson

Alfred Meyer

Max Schellenbaum

Ernst Aufderhaar

Ernst Schweizer

Bernardo De Sousa

Clemens Kocher

Joseph C Boray

Roger K Huff

Oswald Rechsteiner

Jean-Paul Fumeaux

Gedeon Sarasin

The invention relates to novel 5-(azolyloxyphenylcarbamoyl)barbituric acid derivatives of the general formula I ##STR1## wherein X is oxygen or sulfur;

5-(azolyloxyphenylcarbamoyl)barbituric acid derivatives as anthelmintics

The invention relates to novel phenylcarbamoylbarbituric acid derivatives of the general formula ##STR1## wherein R.sub.1 is C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.3 alkoxy, allyl or C.sub.3 -C.sub.6 cycloalkyl,

Barbituric acid derivatives

Novel phenylcarbamoylbarbituric acid derivatives of the general formula I ##STR1## and tautomeric forms and salts thereof in which R.sub.1 and R.sub.2 independently of one another are C.sub.1 -C.sub.5 -alkyl, C.sub.1 -C.sub.3 -alkoxy, C.sub.3 -C.sub.6 -cycloalkyl, allyl or phenyl; R.sub.3 is substituted or unsubstituted pyridyl as herein defined; and X is oxygen or sulfur; they possess anthelmintic activity. The active substances can be employed in conjunction with suitable carriers and further adjuncts for controlling zooparasitic helminths.

5-(pyridyloxy- or pyridylthio-phenyl)carbamoyl barbituric acid

The invention relates to novel 5-phenylcarbamoylthiobarbituric acid derivatives of the general formula ##STR1## wherein R.sub.1 and R.sub.2 are each independently C.sub.1 -C.sub.5 alkyl or methoxy,

Thiobarbituric acid derivatives and their use as anthelminthics

The invention relates to a composition for protecting keratinous material, in particular woollen textiles, from attack by pests that feed on keratin, in particular moth and beetle larvae, which composition contains, as active ingredient combination, a specifically substituted 5-(pyridyloxyphenylcarbamoyl)barbituric acid or a salt thereof and a synthetic pyrethroid, as well as to a process comprising the use of this active ingredient combination for providing said material with a protective finish against attack by pests that feed on keratin.

Mothproofing and beetleproofing composition: 5-(pyridyloxy- or

The invention relates to a process for the manufacture of novel benzazole derivatives of the formula I ##STR1## in which R.sub.1 represents an optionally 4-substituted piperazino group or a group of the formula R.sub.2 --alk--X.sub.2 --,

6-[(4-Substituted piperazin-l-yl)thiocarbonylamino]benzazoles and their

The isothiocyanobenzothiazole derivative of the formula ##STR1## and also salts thereof nontoxic to warm-blooded animals have, besides generally good anthelmintic properties, especially a particularly pronounced action against filariasis, schistosomiasis and gastrointestinal helminths in warm-blooded organisms and equally against liver flukes in sheep. The active substance, together with suitable carriers and additives, is administered perorally or via the abomasum, in the form of solutions, emulsions, suspensions, powders, tablets, boluses and capsules.

6-Isothiocyano-5-methoxy-2-tert.-butylbenzthiazole and a method of

Benzimidazole derivatives of the formula ##STR1## in which R and R.sub.1 independently of one another are each hydrogen, an alkanoyl group having 1 to 4 carbon atoms, an alkoxycarbonyl group having 1 to 4 carbon atoms, an alkylsulphonyl group having 1 to 4 carbon atoms, a benzoyl group, a phenylsulphonyl group or a p-methylphenylsulphonyl group; R.sub.2 and R.sub.4 independently of one another are each hydrogen, halogen or a methyl group, R.sub.3 is hydrogen, halogen, a methyl group or a methoxy group; X is oxygen or sulphur; Y is halogen, an alkyl group having 1 to 4 carbon atoms, an alkoxy group having 1 to 4 carbon atoms, a methylthio group, a methylsulphinyl group, a methylsulphonyl group, a trifluoromethyl group, a nitro group, a hydroxyl group, a cyano group or an acetyl group; and m is 0, 1, 2 or 3; and if one of the two radicals R or R.sub.1 is hydrogen, the position of the other of these radicals on the N atoms cannot be clearly established, including, when at least one of the two radicals R or R.sub.1 is hydrogen, the possible tautomeric compounds of the formula I; and the disulphides obtainable by oxidation of compounds of the formula I. The compounds are useful for combating helminths in domestic animals and productive animals.

Benzimidazole sulphides as anthelmintic agents

Feed additives for promoting the growth of domestic and productive animals, which additives contain as active ingredient at least one compound of the formula I ##STR1## wherein R.sub.1 represents a 5- or 6-membered, N-, S- or O-containing heterocyclic-aromatic radical, optionally substituted by halogen, lower alkyl, phenyl, nitro, cyano, (R.sub.3).sub.2 NCO-, (R.sub.3).sub.2 N--, R.sub.3 O--, R.sub.3 SO.sub.2 --, R.sub.3 SO- or R.sub.3 S--,

Growth promoting feed additive oxadiazines

New diazine derivatives corresponding to the formula ##STR1## wherein R.sub.1 denotes a heterocyclic-aromatic radical which is optionally substituted by halogen, lower alkyl, aryl, nitro, cyano, trifluoromethyl, carboxyl, R.sub.3 OOC--, (R.sub.3).sub.2 NCO--, (R.sub.3).sub.2 N--, R.sub.3 O--, R.sub.3 SO.sub.2 --, R.sub.3 SO-- or R.sub.3 S--, and R.sub.2 and R.sub.3 independently of one another denote lower alkyl, alkoxyalkyl, alkenyl or cycloalkyl which is optionally bonded via an alkylene bridge, processes for the production of the new compounds, compositions containing these compounds and a process for combating Coccidia.

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Magden, Switzerland

Jean J Gallay