Institut Pasteur

Centre National De La Recherche Scientifique

Jean Igolen

Tam Huynh Dinh

Catherine Gouyette

Luc Montagnier

Francoise Barre-Sinoussi

Jean-Francois Nicolas

Robert M Fauve

Yvette Henin

Bernadette Dupraz

Tam Huynh-Dinh

Olivier Schwartz

Nathalie Savatier

A compound having the following formula I: ##STR1## in which: R' represents a hydrogen atom or an azido group,

Glucosyl phosphotriesters of thymidine

The glycosylphospholipid nucleoside derivatives of the invention are based on the formula: ##STR1## wherein: R.sub.1 is a nucleoside derivative selected from the group consisting of 3'-azidothymidine (AZT); 2', 3'-dideoxythymidine (ddT); and 2'-deoxy-5-fluorouridine (dFU);

Glycosyl phospholipid derivatives of nucleosides and their use as

The invention concerns 2,N.sup.6 -disubstituted and 2,N.sup.6 -trisubstituted adenosine nucleosides in which the sugar component is substituted at position 3' or position 5' by a phosphite or phosphoramidite group of the formula: ##STR1## R.sub.1 representing a lower alkyl or --(CH.sub.2).sub.n --CN with n being an integer between 1 and 4, and X representing a halogen or an amine group. These nucleosides make it possible to prepare sequences of nucleotides usable, in particular, as probes in the field of analyses and biological extractions.

2,N.sup.6 -disubstituted and 2,N.sup.6 -trisubstituted

The invention relates to a probe constituted by an oligonucleotide fragment of structure predetermined by the application envisaged, wherein at least a part of the adenine groups therein is replaced by modified adenine groups so that they can form three hydrogen bonds with the reactive groups of thymine or uracil. This probe is useful in the field of biological analyses and extractions.

Probes comprising modified adenine groups, their preparation and their

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Le Mesnil St-Denis, France

Jean Igolen