The University of Toledo

Jean H Overmeyer

Paul W Erhardt

William A Maltese

Christopher J Trabbic

Michael W Robinson

The present invention provides materials and methods to induce cell death by methuosis, a non-apoptotic cell death mechanism, to induce vacuolization without cell death, or to induce cell death without vacuolization. Small molecules herein are useful for treating cell proliferation disorders or anomalies, particularly, but not exclusively, cancer. Methods related to the research and pharmaceutical use of the small molecules are also provided herein.

Materials and methods useful to induce vacuolization, cell death, or a combination thereof

The present invention provides materials and methods to induce cell death by methuosis, a non-apoptotic cell death mechanism. Small molecules herein are useful for treating cell proliferation disorders or anomalies, particularly, but not exclusively, cancer. Methods related to the research and pharmaceutical use of the small molecules are also provided herein.

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Perrysburg, OH, United States of America

Jean H Overmeyer