Massachusetts Institute of Technology

Centre National De La Recherche Scientifique

Institut Pasteur

Jean G Guillet

Arthur Donny Strosberg

Johan Hoebeke

Malcolm L Gefter

Cuong Tram

Novel methods or compositions are provided for modulating the immune system, so as to be able to selectively stimulate or inactivate lymphocytes in relation to a particular transplantation antigen content. Particularly, mixtures may be employed associated with the more common transplanatation antigens of a host population. In this manner, a large number of people can be treated, for example, by immunization, stimulation of particular T-cells or B-cells in relation to a pathogenic invasion of other aberrant state, e.g. neoplasia, treatment of autoimmune diseases, and the like. Particularly, the compositions may involve an oligopeptide involving as a first region a consensus sequence and an epitope or the first region may be joined to a second region comprising an antibody target sequence which is capable of competing with an epitopic site of an antigen of interest.

Immunonodulating compositions and their use

A process to produce hybrid cell lines, which produce monoclonal antibodies to Legionella pneumophila. Cell lines are produced by fusion of immunized mouse splenocytes to these bacteria with non secreting myeloma cells. Monoclonal antibodies are useful for diagnosis of diseases due to Legionella pneumophilia, for detection of these bacteria in environment, for the production of vaccines.

Monoclonal antibodies to legionella, a process for their preparation and

Growing community of inventors

Paris, France

Jean G Guillet