Commissariat a L'energie Atomique

Commissariat &#xc0; L'&#xc9;nergie Atomique Et Aux &#xc9;nergies Alternatives

Serono Genetics Institute S.a.

Genset S.a.

Jean-Frederic Clerc

Yves Fouillet

Claude Vauchier

Christine Peponnet

Serge Gidon

Raymond Charles

Nicolas Sarrut

Laurent Vandroux

Alain Soubie

Patricia Claustre

Alain-Marcel Rey

Gilles Le Carval

An object including at least one graphic element, including at least one at least partly transparent substrate, at least one face of which includes recesses forming a pattern of the graphic element filled with the at least one material, the face of the substrate being fixed to at least one face of at least one support by wafer bonding, the substrate and the support forming a monolithic structure.

Object provided with a graphic element transferred on a support and method for making such an object

A storage layer is arranged facing an array of micro-tips. The storage layer includes a plurality of insulated conductive dots designed to store electric charges. Each micro-tip includes a high-permittivity element integral to a transistor channel connecting a source and a drain. The channel has a conductance able to be modified by the electric field created by the charge of the dot arranged facing the high-permittivity element. The system can include an actuator for relative displacement of the storage layer with respect to the micro-tips. The system can include an array of electrodes able to cause displacement of the charges from one dot to the other.

Data recording system and method for using same

Provided is a microfluidic device comprising a microfluidic substrate comprising at least one pathway for sample flow; and at least one thermal transfer member which is capable of cycling between at least two temperatures. The thermal transfer member is adapted to heat at least a portion of the sample pathway while a sample is flowing along said at least a portion of said sample pathway. Provided also are methods of carrying out biochemical protocols using such a device.

Microfluidic devices and uses thereof in biochemical processes

Devices and methods for carrying out a chemical or biochemical protocol are disclosed. In one embodiment, the chemical or biochemical protocol is performed by cycling at least one thermal transfer member between at least two temperatures while liquid samples on which the chemical or biochemical protocol is to be performed are continuously moving through at least one temperature regulated zone upon which the at least one thermal transfer member acts. In some embodiments, the device comprises a sample transport member that comprises liquid samples in sample receiving regions. The sample transport member moves the samples continuously through a temperature regulated zone which cycles between at least two temperatures while the liquid samples are moving through a temperature regulated zone on which at least one thermal transfer member acts. In some embodiments, the sample receiving regions comprise wells, hydrophillic films or hydrophillic filaments.

Method for carrying out a biochemical protocol in continuous flow in a microreactor

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Brie et Angonnes, France

Jean-Frederic Clerc