Institut National De La Sante Et De La Recherche Medicale

Assistance Publique-hopitaux De Paris

Centre National De La Recherche Scientifique

Sorbonne Université

Université Paris Descartes—paris V

Jean-François Bach

Anne Marie Joutel

Elisabeth Andree Tournier-Lasserve

Marie-Germaine Madeleine Bousser

Jean-Marie Pleau

Mireille Dardenne

Lucienne Chatenoud

Jocelyne Just

Bared Safieh-Garabedian

Nayef Saade

Bénédicte Michaud

The present invention relates to the utilization of peptide analogues of thymulin that are inactive relative to the immune system, not comprising zinc and having anti-pain activity, for manufacturing a medicine for the treatment of pain.

Use of thymulin-like peptides for making pain-relieving medicines

The invention concerns the Notch3 gene and the corresponding protein, which are involved in CADASIL. The invention concerns, in particular, methods for demonstrating mutations in this gene, which are linked to the risk of developing CADASIL and related diseases.

Gene involved in CADASIL, method of diagnosis and therapeutic application

The invention concerns the Notch3 gene and the corresponding protein, which are involved in CADASIL. The invention concerns, in particular, methods for demonstrating mutations in this gene, which are linked to the risk of developing CADASIL. The invention also concerns models and products for treating CADASIL and related diseases.

Growing community of inventors

Paris, France

Jean-François Bach