Agence Nationale De Valorisation De La Recherche (anvar)

Agence Nationale De Valorisation

The Agence Nationale De Valorisation De Le Recherche

Jean-Francois Petit

Louis A Chedid

Edgar Lederer

Arlette Adam

Rita Ciorbaru

Jean Choay

Pierre Lefrancier

Francoise Marguerite Audibert

Frank M Berger

Pierre G Sinay

Claude Merser

Fabrielle Ellouz

Dominique Juy

Constantin Bona

Chantal, Born Damais

Rita Ciorbaru Nee Sfartz

Rita, Born Ciorbaru

Arlette, Born Adam

Water soluble agents effective as immunological adjuvants for stimulating in the host the immune response to various antigens, comprising an acyl-muramic acid group, wherein acyl means acetyl or glycolyl, and a short peptide chain linked to said acyl-muramic acid group, the first and second amino acids of said peptide chain being preferentially alanine and glutamic acid respectively.

Water soluble agents effective as immunological adjuvants for

The invention relates to a process for obtaining agents having mitogenic and/or adjuvant properties, from Nocardia cells. According to this process Nocardia whole cells are subjected to a rupturing treatment of their walls within an aqueous medium, particularly distilled water. After the separation of the non-ruptured cells and of the wall fragments of the ruptured cells, mitogenic agents are extracted from the remaining aqueous phase. The fractions obtained are useful as laboratory reagents and for the production of medicamentous compositions in which they are associated with a pharmaceutical vehicle.

Process for obtaining agents having mitogenic and/or adjuvant properties

The present invention relates to novel immunological agents effective as adjuvants for stimulating an immune response to various types of antigens. The adjuvants do not cause objectionable reactions and they are easily purified. The invention additionally relates to a process for producing the novel adjuvants.

Immunological agents

The invention pertains to a mitrogenic agent and to a process for obtaining same. It comprises the steps of cultivating Nocardiae cells, collecting them, subjecting them to a treatment for rupturing the integrity of their walls, such as by lysis, discarding the solid residue and collecting the aqueous fraction, causing the peptidoglycane fragments contained in this aqueous fraction to be separated therefrom and recovering the remaining fraction containing the mitogenic agent.

Water-soluble agents having mitogenic properties obtained from nocardia

Water-soluble immunological adjuvants, extracted from mycobacteria and nocardia cells, useful for stimulating, in a host, the immune response to various kinds of antigens.

Process for preparing vaccine adjuvant

The invention pertains to a water-soluble immunological adjuvant, especially for vaccines. It is obtained by enzymatic treatment of mycobacteria or Nocardia whole cells in aqueous medium and by a recovery from said aqueous medium.

Water-soluble immunological adjuvants, in particular for vaccines,

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Paris, France

Jean-Francois Petit